Spironolactone Administration and Training-Induced Hypervolemia

Abstract The purpose of this study was to determine the contribution of aldosterone to plasma volume expansion accompanying short-term exercise training. Twelve healthy males (age = 26.5±5.8) cycled for 120 min on three consecutive days at a relative exercise intensity of 65% V̇O 2 max. Half of the subjects were treated with 25 mg of spironolactone taken four times daily to suppress the effects of aldosterone. Resting plasma volume increased significantly (501±83 ml, p