The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA

A 2618-bp cDNA that encodes the human mitochondrial glycerol-3-phosphate dehydrogenase has been isolated from a HeLa cell cDNA library and the nucleotide sequence determined. An open reading frame encodes a protein of 727 amino acids that is 96% similar to the rat protein and, like the rat protein,...

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Veröffentlicht in:	Gene 1994, Vol.150 (2), p.417-418
Hauptverfasser:	Lehn, Donald A., Brown, Laura J., Simonson, Gregg D., Moran, Susan M., MacDonald, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino-acid homology Animals Base Sequence Binding Sites Calcium - metabolism calcium-binding sites Calmodulin - metabolism cDNA DNA, Complementary Flavin-Adenine Dinucleotide - metabolism Gene Library genes glycerol-3-phosphate dehydrogenase Glycerolphosphate Dehydrogenase - genetics Glycerophosphates - metabolism HeLa cell HeLa Cells Hominidae - genetics Human cDNA library Humans inner membranes man mitochondria Molecular Sequence Data nuclear encoded nucleotide sequence Open Reading Frames prediction Rats Sequence Homology, Amino Acid
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Beschreibung
Zusammenfassung:	A 2618-bp cDNA that encodes the human mitochondrial glycerol-3-phosphate dehydrogenase has been isolated from a HeLa cell cDNA library and the nucleotide sequence determined. An open reading frame encodes a protein of 727 amino acids that is 96% similar to the rat protein and, like the rat protein, contains sites homologous to the Ca 2+ -binding sites of calmodulin, as well as FAD- and putative glycerol-phosphate-binding sites.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(94)90469-3