Reduced responsiveness of touch (SA I) receptors in the cat following close arterial infusion of neomycin

Electrophysiological recording were made from afferent nerve fibres supplying slowly adapting type I (SA I) cutaneous mechanoreceptors in the cat during application of mechanical stimuli (20 mN constant force, 0.2 s rise time and 2 s plateau phase, every 30 s). Close arterial infusion of neomycin (2.5 mg/min for 5 min) strongly depressed the responsiveness of SA I receptors. A direct effect on the receptor is thought to be the mode of action.