Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides

The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of epidemiology 1994-04, Vol.10 (2), p.235-237
Hauptverfasser: Rivanera, D., Lorino, G., Lilli, D., Dicuonzo, G., Mancini, C.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 237
container_issue 2
container_start_page 235
container_title European journal of epidemiology
container_volume 10
creator Rivanera, D.
Lorino, G.
Lilli, D.
Dicuonzo, G.
Mancini, C.
description The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.
doi_str_mv 10.1007/BF01730378
format Article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76926232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3521228</jstor_id><sourcerecordid>3521228</sourcerecordid><originalsourceid>FETCH-LOGICAL-c291t-d53aa26c78edb7ce0dde78eef51248f51c5bf698534e433cb7de2d5d3179f9163</originalsourceid><addsrcrecordid>eNpF0MtLxDAQBvAgiq6Pi2eFHMSDUM2jaZqjLr5AUPABnkqaTDXSbddMKux_b2WX9ZIJfD-G4SPkkLNzzpi-uLphXEsmdblBJlxpmWlR5ptkwqSRmTCG7ZBdxC_GWMmM2ibbWgnDTTEh79c_th1sCn1H-4bedx4SxFnobAL6DNHSpo_0DuYjSQHplL6FOCCtF_QS0S6QvmLoPujzokufkIKjTzBPwQPuk63GtggHq7lHXm-uX6Z32cPj7f308iFz4wkp80paKwqnS_C1dsC8h_EPjeIiL8fXqbopTKlkDrmUrtYehFdecm0awwu5R06Xe-ex_x4AUzUL6KBtbQf9gJUujCiEFCM8W0IXe8QITTWPYWbjouKs-uux-u9xxMerrUM9A7-mq-LG_GSVW3S2baLtXMA1y0VecMlHdrRkX5j6uI6lElyIUv4CGrODVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76926232</pqid></control><display><type>article</type><title>Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rivanera, D. ; Lorino, G. ; Lilli, D. ; Dicuonzo, G. ; Mancini, C.</creator><creatorcontrib>Rivanera, D. ; Lorino, G. ; Lilli, D. ; Dicuonzo, G. ; Mancini, C.</creatorcontrib><description>The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.</description><identifier>ISSN: 0393-2990</identifier><identifier>ISSN: 0392-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/BF01730378</identifier><identifier>PMID: 7529196</identifier><language>eng</language><publisher>Dordrecht: Kluwer Academic Publishers</publisher><subject>Antibodies ; Biological and medical sciences ; Brief Reports ; Enzyme linked immunosorbent assay ; Epitopes ; Evaluation Studies as Topic ; Fundamental and applied biological sciences. Psychology ; Genomes ; Hepacivirus ; Hepacivirus - immunology ; Hepatitis ; Hepatitis Antibodies - blood ; Hepatitis C - blood ; Hepatitis C - epidemiology ; Hepatitis C Antibodies ; Humans ; Immunoblotting - methods ; Infections ; Microbiology ; Peptides ; Reactivity ; Recombinant antigens ; Sensitivity and Specificity ; Techniques used in virology ; Test systems ; Virology</subject><ispartof>European journal of epidemiology, 1994-04, Vol.10 (2), p.235-237</ispartof><rights>Copyright 1994 Kluwer Academic Publishers</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c291t-d53aa26c78edb7ce0dde78eef51248f51c5bf698534e433cb7de2d5d3179f9163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3521228$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3521228$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4246131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7529196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivanera, D.</creatorcontrib><creatorcontrib>Lorino, G.</creatorcontrib><creatorcontrib>Lilli, D.</creatorcontrib><creatorcontrib>Dicuonzo, G.</creatorcontrib><creatorcontrib>Mancini, C.</creatorcontrib><title>Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><description>The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.</description><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Brief Reports</subject><subject>Enzyme linked immunosorbent assay</subject><subject>Epitopes</subject><subject>Evaluation Studies as Topic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genomes</subject><subject>Hepacivirus</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C Antibodies</subject><subject>Humans</subject><subject>Immunoblotting - methods</subject><subject>Infections</subject><subject>Microbiology</subject><subject>Peptides</subject><subject>Reactivity</subject><subject>Recombinant antigens</subject><subject>Sensitivity and Specificity</subject><subject>Techniques used in virology</subject><subject>Test systems</subject><subject>Virology</subject><issn>0393-2990</issn><issn>0392-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MtLxDAQBvAgiq6Pi2eFHMSDUM2jaZqjLr5AUPABnkqaTDXSbddMKux_b2WX9ZIJfD-G4SPkkLNzzpi-uLphXEsmdblBJlxpmWlR5ptkwqSRmTCG7ZBdxC_GWMmM2ibbWgnDTTEh79c_th1sCn1H-4bedx4SxFnobAL6DNHSpo_0DuYjSQHplL6FOCCtF_QS0S6QvmLoPujzokufkIKjTzBPwQPuk63GtggHq7lHXm-uX6Z32cPj7f308iFz4wkp80paKwqnS_C1dsC8h_EPjeIiL8fXqbopTKlkDrmUrtYehFdecm0awwu5R06Xe-ex_x4AUzUL6KBtbQf9gJUujCiEFCM8W0IXe8QITTWPYWbjouKs-uux-u9xxMerrUM9A7-mq-LG_GSVW3S2baLtXMA1y0VecMlHdrRkX5j6uI6lElyIUv4CGrODVA</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Rivanera, D.</creator><creator>Lorino, G.</creator><creator>Lilli, D.</creator><creator>Dicuonzo, G.</creator><creator>Mancini, C.</creator><general>Kluwer Academic Publishers</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides</title><author>Rivanera, D. ; Lorino, G. ; Lilli, D. ; Dicuonzo, G. ; Mancini, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-d53aa26c78edb7ce0dde78eef51248f51c5bf698534e433cb7de2d5d3179f9163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Brief Reports</topic><topic>Enzyme linked immunosorbent assay</topic><topic>Epitopes</topic><topic>Evaluation Studies as Topic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genomes</topic><topic>Hepacivirus</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C Antibodies</topic><topic>Humans</topic><topic>Immunoblotting - methods</topic><topic>Infections</topic><topic>Microbiology</topic><topic>Peptides</topic><topic>Reactivity</topic><topic>Recombinant antigens</topic><topic>Sensitivity and Specificity</topic><topic>Techniques used in virology</topic><topic>Test systems</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivanera, D.</creatorcontrib><creatorcontrib>Lorino, G.</creatorcontrib><creatorcontrib>Lilli, D.</creatorcontrib><creatorcontrib>Dicuonzo, G.</creatorcontrib><creatorcontrib>Mancini, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivanera, D.</au><au>Lorino, G.</au><au>Lilli, D.</au><au>Dicuonzo, G.</au><au>Mancini, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides</atitle><jtitle>European journal of epidemiology</jtitle><addtitle>Eur J Epidemiol</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>10</volume><issue>2</issue><spage>235</spage><epage>237</epage><pages>235-237</pages><issn>0393-2990</issn><issn>0392-2990</issn><eissn>1573-7284</eissn><abstract>The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.</abstract><cop>Dordrecht</cop><pub>Kluwer Academic Publishers</pub><pmid>7529196</pmid><doi>10.1007/BF01730378</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0393-2990
ispartof European journal of epidemiology, 1994-04, Vol.10 (2), p.235-237
issn 0393-2990
0392-2990
1573-7284
language eng
recordid cdi_proquest_miscellaneous_76926232
source Jstor Complete Legacy; MEDLINE; SpringerLink Journals - AutoHoldings
subjects Antibodies
Biological and medical sciences
Brief Reports
Enzyme linked immunosorbent assay
Epitopes
Evaluation Studies as Topic
Fundamental and applied biological sciences. Psychology
Genomes
Hepacivirus
Hepacivirus - immunology
Hepatitis
Hepatitis Antibodies - blood
Hepatitis C - blood
Hepatitis C - epidemiology
Hepatitis C Antibodies
Humans
Immunoblotting - methods
Infections
Microbiology
Peptides
Reactivity
Recombinant antigens
Sensitivity and Specificity
Techniques used in virology
Test systems
Virology
title Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T22%3A21%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20Indeterminate%20Sera%20for%20Hepatitis%20C%20Virus%20by%20Assays%20Using%20Synthetic%20Peptides&rft.jtitle=European%20journal%20of%20epidemiology&rft.au=Rivanera,%20D.&rft.date=1994-04-01&rft.volume=10&rft.issue=2&rft.spage=235&rft.epage=237&rft.pages=235-237&rft.issn=0393-2990&rft.eissn=1573-7284&rft_id=info:doi/10.1007/BF01730378&rft_dat=%3Cjstor_proqu%3E3521228%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76926232&rft_id=info:pmid/7529196&rft_jstor_id=3521228&rfr_iscdi=true