Evaluation of Indeterminate Sera for Hepatitis C Virus by Assays Using Synthetic Peptides

The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated...

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Veröffentlicht in:	European journal of epidemiology 1994-04, Vol.10 (2), p.235-237
Hauptverfasser:	Rivanera, D., Lorino, G., Lilli, D., Dicuonzo, G., Mancini, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological and medical sciences Brief Reports Enzyme linked immunosorbent assay Epitopes Evaluation Studies as Topic Fundamental and applied biological sciences. Psychology Genomes Hepacivirus Hepacivirus - immunology Hepatitis Hepatitis Antibodies - blood Hepatitis C - blood Hepatitis C - epidemiology Hepatitis C Antibodies Humans Immunoblotting - methods Infections Microbiology Peptides Reactivity Recombinant antigens Sensitivity and Specificity Techniques used in virology Test systems Virology
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Zusammenfassung:	The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.
ISSN:	0393-2990 0392-2990 1573-7284
DOI:	10.1007/BF01730378