The heregulin gene can be included in the 8p12 amplification unit in human breast cancer

The Heregulin (HGL) gene, encoding a ligand for a member of the ERBB receptor family, is located at 8p 12‐p22, in or close to a region frequently amplified in breast carcinoma. Amplification of HGL was detected in three of 83 (3.6%) cases of breast tumors. No overexpression of the gene was observed...

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Veröffentlicht in:	Genes chromosomes & cancer 1994-09, Vol.11 (1), p.66-69
Hauptverfasser:	Adélaïe, José, Penault-Llorca, Frédérique, Dib, Amel, Yarden, Yosef, Jacquemier, Jocelyne, Birnbaum, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	breast Breast Neoplasms - genetics carcinoma chromosome 8 Chromosomes, Human, Pair 8 DNA, Neoplasm - genetics Gene Amplification Gene Expression Regulation, Neoplastic Genetic Markers Glycoproteins - genetics heregulin gene Humans man Multigene Family Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neuregulins Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptors, Fibroblast Growth Factor - genetics RNA, Neoplasm - genetics
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Beschreibung
Zusammenfassung:	The Heregulin (HGL) gene, encoding a ligand for a member of the ERBB receptor family, is located at 8p 12‐p22, in or close to a region frequently amplified in breast carcinoma. Amplification of HGL was detected in three of 83 (3.6%) cases of breast tumors. No overexpression of the gene was observed in the amplified tumors. This and the low incidence of amplification suggest that HGL is not the key gene of the 8p 12 amplification but may be used as a marker of large amplification units.
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.2870110111