Identification of a putative second T-cell receptor

Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) alpha- and beta-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appear...

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Veröffentlicht in:	Nature (London) 1986-07, Vol.322 (6075), p.145-149
Hauptverfasser:	Dialynas, Deno P, Krangel, Michael S, Brenner, Michael B, Strominger, Jack L, Smith, John A, Ip, Stephen, Rosen, Fred, McLean, Joanne, Owen, Frances L, Seidman, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal Biological and medical sciences Cell Line DNA Electrophoresis Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunologic Deficiency Syndromes - immunology Nucleic Acid Hybridization Organs and cells involved in the immune response Receptors, Antigen, T-Cell - analysis
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Beschreibung
Zusammenfassung:	Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) alpha- and beta-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be the product of the T gamma gene. The other polypeptide may represent a fourth TCR subunit, designated T delta.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/322145a0