Cytotoxic and antiparasitic activity from Annona senegalensis seeds

Cytotoxic and antiparasitic activity from Annona senegalensis seeds

Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity against KB and VERO cell lines. Fractionation of seeds extracts was mainly guided by means of a bioci...

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Veröffentlicht in:Planta medica 1994-12, Vol.60 (6), p.538-540
Hauptverfasser: Sahpaz, S, Bories, C, Loiseau, P.M, Cortes, D, Hocquemiller, R, Laurens, A, Cave, A. (Paris-Sud Univ., Chatenay-Malabry (France). Faculte de Pharmacie. Lab. de Pharmacognosie)
Format: Artikel
Sprache:eng
Schlagworte:
acetogenins
Animals
ANNONA SENEGALENSIS
Annonaceae
Antineoplastic Agents, Phytogenic - pharmacology
Antiprotozoal Agents - pharmacology
Artemia - drug effects
ARTEMIA SALINA
Biological and medical sciences
Cercopithecus aethiops
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
cytotoxicity
Drug Screening Assays, Antitumor
FARMACOLOGIA
General pharmacology
GRAINE
Humans
Leishmania
Leishmania - drug effects
LEISHMANIA DONOVANI
Medical sciences
Pflanzenbau
Pharmacognosy. Homeopathy. Health food
PHARMACOLOGIE
Pharmacology. Drug treatments
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
Seeds
SEMILLA
TOXICIDAD
TOXICITE
Trypanocidal Agents - pharmacology
Trypanosoma
TRYPANOSOMA BRUCEI
Trypanosoma brucei brucei - drug effects
Tumor Cells, Cultured
Vero Cells
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Beschreibung
Zusammenfassung:Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity against KB and VERO cell lines. Fractionation of seeds extracts was mainly guided by means of a biocidal assay against Artemia salina nauplii. The biological activities resulted from extract-isolated acetogenins.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-959566