Phylogenetic analysis of the rpoB gene from the plastid-like DNA of Plasmodium falciparum

Malaria and other Apicomplexan parasites harbour two extrachromosomal DNAs. One is mitochondrial and the other is a 35-kb circle with some plastid-like features but whose provenance and function is unknown. In addition to genes for rRNAs, tRNAs and ribosomal proteins, the 35-kb circular DNA of Plasm...

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Veröffentlicht in:	Molecular and biochemical parasitology 1994-08, Vol.66 (2), p.221-231
Hauptverfasser:	Gardner, Malcolm J., Goldman, Nick, Barnett, Phillip, Moore, Peter W., Rangachari, Kaveri, Strath, Malcolm, Whyte, Andrea, Williamson, Donald H., Wilson, Robert J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Codon - genetics DNA Primers - genetics DNA, Circular - genetics DNA, Protozoan - genetics DNA-Directed RNA Polymerases - genetics Extrachromosomal Inheritance Fundamental and applied biological sciences. Psychology Genes, Protozoan Invertebrates Malaria Molecular Sequence Data Phylogeny Plasmodium falciparum Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Plastid Plastids - genetics Protozoa RNA polymerase rpoB Sequence Homology, Amino Acid Species Specificity
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Zusammenfassung:	Malaria and other Apicomplexan parasites harbour two extrachromosomal DNAs. One is mitochondrial and the other is a 35-kb circle with some plastid-like features but whose provenance and function is unknown. In addition to genes for rRNAs, tRNAs and ribosomal proteins, the 35-kb circular DNA of Plasmodium falciparum carries an rpoBC operon which encodes subunits of a eubacteria-like RNA polymerase. The phylogenetic analysis of the complete rpoB sequence presented here supports our inference that the 35-kb circle is the remnant of a plastid genome.
ISSN:	0166-6851 1872-9428
DOI:	10.1016/0166-6851(94)90149-X