New Cytotoxic Peroxylactones from the Marine Sponge, Plakinastrella onkodes

Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxy ester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortol...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1994-10, Vol.57 (10), p.1374-1381
Hauptverfasser:	Horton, Paul A, Longley, Ross E, Kelly-Borges, Michelle, McConnell, Oliver J, Ballas, Larry M
Format:	Artikel
Sprache:	eng
Schlagworte:	AGENTES ANTINEOPLASTICOS Animals ANTINEOPLASTIC AGENTS Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology CARCINOMA CARCINOME Cell Adhesion - drug effects Cell Line Cell Survival - drug effects CHEMICAL COMPOSITION COMPOSICION QUIMICA COMPOSITION CHIMIQUE CYTOTOXIC COMPOUNDS epiplakinic acid ESPECTROMETRIA ESTER ESTERES ESTERS GOLFE DU MEXIQUE GOLFO DE MEXICO GULF OF MEXICO Humans LACTONAS LACTONE LACTONES Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology LEUCEMIA LEUCEMIE LEUKAEMIA LEUKEMIA Leukemia P388 - drug therapy LUNGS Magnetic Resonance Spectroscopy Marine MEDICAMENT CYTOSTATIQUE Mice MOLECULAR CONFORMATION PARAZOA Plakinastrella onkodes plakortolides Porifera - chemistry POUMON PULMONES SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY SUBSTANCE TOXIQUE SUSTANCIAS TOXICAS TOXIC SUBSTANCES Tumor Cells, Cultured
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Zusammenfassung:	Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxy ester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [8], and epiplakinic acid E methyl ester [9], were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.IL-2 cell line, which correlates with signal transduction activity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50112a006