Natural Course of Insulin Resistance in Type I Diabetes

To examine the natural course of insulin action in Type I diabetes, we followed 15 patients prospectively for one year after the diagnosis of diabetes and also performed a cross-sectional study of 53 additional patients who had had diabetes for 2 to 32 years. Two weeks after diagnosis, the rate of g...

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Veröffentlicht in:	The New England journal of medicine 1986-07, Vol.315 (4), p.224-230
Hauptverfasser:	Yki-Järvinen, Hannele, Koivisto, Veikko A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Glucose - metabolism Body weight C-Peptide - blood Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Diagnosis Drug dosages Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Female Glucose Humans Hyperinsulinemia Insulin Insulin - administration & dosage Insulin - metabolism Insulin Resistance Insulin Secretion Male Medical sciences Middle Aged Peptides Prospective Studies Remission Remission, Spontaneous Secretion
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Zusammenfassung:	To examine the natural course of insulin action in Type I diabetes, we followed 15 patients prospectively for one year after the diagnosis of diabetes and also performed a cross-sectional study of 53 additional patients who had had diabetes for 2 to 32 years. Two weeks after diagnosis, the rate of glucose uptake during hyperinsulinemia, a measure of insulin action, was 32 percent lower in the patients with diabetes than in 30 matched normal subjects (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198607243150404