Effect of Dentifrice Containing Lysozyme Chloride on Periodontal Disease

The purpose of the present study was to evaluate the effect of a new dentifrice containing lysozyme chloride and sodium fluoride on periodontal disease by the double blind test. Sixty-seven students with gingivitis were directed to clean the teeth with the dentifrice for four weeks. They were devided into three groups; using placebo dentifrice (control group), using dentifrice containing chlorhexidine (chlorhexidine group) and using dentifrice containing lysozyme chloride and sodium fluoride (lysozyme group). In three groups, redness, swelling of gingiva, depth of periodontal pockets and bleeding on probing were improved during whole experiment. Significant difference was observed in the percent improvement of the redness and the swelling between the lysozyme group and the others (x2-test). It suggests that the new dentifrice possessed a part of an anti-inflammatory effect. The use of this dentifrice may enhance the clinical effect of toothbrushing on periodontal disease.