CALOPOROSIDE, A NEW INHIBITOR OF PHOSPHOLIPASES C FROM Caloporus dichrous (Fr.) Ryv

A new salicylic acid derivative, caloporoside, was isolated from fermentations of Caloporus dichrous. Its structure was elucidated by a combination of chemical and spectroscopic methods. Caloporoside exhibits weak antibacterial and antifungal activities and is a quite selective inhibitor of phosphol...

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Veröffentlicht in:	Journal of antibiotics 1994/11/25, Vol.47(11), pp.1188-1194
Hauptverfasser:	WEBER, WOLFGANG, SCHU, PETER, ANKE, TIMM, VELTEN, ROBERT, STEGLICH, WOLFGANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Basidiomycota - metabolism Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Mannose - analogs & derivatives Mannose - chemistry Mannose - isolation & purification Mannose - pharmacology Medical sciences Pharmacology. Drug treatments Salicylates - chemistry Salicylates - isolation & purification Salicylates - pharmacology Swine Type C Phospholipases - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	A new salicylic acid derivative, caloporoside, was isolated from fermentations of Caloporus dichrous. Its structure was elucidated by a combination of chemical and spectroscopic methods. Caloporoside exhibits weak antibacterial and antifungal activities and is a quite selective inhibitor of phospholipase C isolated from pig brain (Ki 12, 3μm).
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.47.1188