Elevated natural killer cytotoxicity in HLA-B8 and HLA-DR3-positive individuals

Increased natural killer cytotoxicity in persons positive for HLA-B8 and HLA-DR3 has been found. It is suggested that linkage disequilibrium between the genes coding for HLA-B8 and HLA-DR3 may have evolved as a result of strengthened immunological surveillance in individuals bearing them, as decreas...

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Veröffentlicht in:	Immunology letters 1986-03, Vol.12 (2), p.61-63
Hauptverfasser:	Jakobisiak, Marek, Saidman, Susan, Schlaut, Joy, Pazderka, Feldgerita, Dossetor, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Applied sciences Cytotoxicity, Immunologic Exact sciences and technology Female Genes, MHC Class II Genetic Linkage Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology HLA Antigens - genetics HLA Antigens - immunology HLA-B8 HLA-B8 Antigen HLA-DR3 HLA-DR3 Antigen Humans Immunity, Cellular Immunologic Surveillance Killer Cells, Natural - immunology Male Middle Aged natural killer cytotoxicity Other techniques and industries
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Beschreibung
Zusammenfassung:	Increased natural killer cytotoxicity in persons positive for HLA-B8 and HLA-DR3 has been found. It is suggested that linkage disequilibrium between the genes coding for HLA-B8 and HLA-DR3 may have evolved as a result of strengthened immunological surveillance in individuals bearing them, as decrease in the frequency of both these antigens has recently been reported in patients with tumours.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/0165-2478(86)90083-0