Interferon: a cytotoxic T lymphocyte differentiation signal

Human T cell clones which were able to proliferate in response to specific stimuli but could not kill even in the presence of lectins were found to acquire the specific lytic function when interferon alpha or gamma was added on day 1 of the 7‐day restimulation culture. These results demonstrate that...

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Veröffentlicht in:	European journal of immunology 1986, Vol.16 (7), p.767-770
Hauptverfasser:	Chen, Likuang, Tourvieille, Bcatrice, Burns, Gordon F., Bach, Fritz H., Mathieu‐Mahul, Danièle, Sasportes, Marilyne, Bensussan, Armand
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Antigens, Surface - immunology Biological and medical sciences Cell Differentiation - drug effects Clone Cells Cytotoxicity, Immunologic - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interferon Type I - pharmacology Interferon-gamma - pharmacology Organs and cells involved in the immune response T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology
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Zusammenfassung:	Human T cell clones which were able to proliferate in response to specific stimuli but could not kill even in the presence of lectins were found to acquire the specific lytic function when interferon alpha or gamma was added on day 1 of the 7‐day restimulation culture. These results demonstrate that interferon may act as a cytotoxic T lymphocyte differentiation signal. This signal can be blocked by the monoclonal antibody LeoA1 which recognizes a 70‐kDa cell surface structure, involved in cytotoxic T lymphocyte differentiation.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830160709