Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart
The (+)-enantiomer of the dihydropydine 202–791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (-)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the my...
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| Veröffentlicht in: | European journal of pharmacology 1986-04, Vol.123 (3), p.455-458 |
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| container_end_page | 458 |
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| container_issue | 3 |
| container_start_page | 455 |
| container_title | European journal of pharmacology |
| container_volume | 123 |
| creator | Uematsu, Toshihiko Cook, Nigel S. Hof, Robert P. Vozeh, Samuel Follath, Ferenc |
| description | The (+)-enantiomer of the dihydropydine 202–791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (-)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (-)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therfore be considered when the potential therapeutic uses of calcium channel activators are discussed. |
| doi_str_mv | 10.1016/0014-2999(86)90723-5 |
| format | Article |
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Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (-)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therfore be considered when the potential therapeutic uses of calcium channel activators are discussed.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(86)90723-5</identifier><identifier>PMID: 3720830</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - physiopathology ; Ca channel activator ; Ca channel blocker ; calcium ; Coronary Circulation - drug effects ; Coronary Disease - complications ; Coronary Disease - physiopathology ; Coronary ligation-reperfusion arrhythmias ; dihydropyridine ; heart ; Langendorff perfused rat heart ; Male ; Myocardial Contraction - drug effects ; Rats ; Rats, Inbred Strains ; Stereoisomerism</subject><ispartof>European journal of pharmacology, 1986-04, Vol.123 (3), p.455-458</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-726dbf50c128ea40b3d8eacebc68b5ca023d2d289893eae7e6a14c7ce3bcbc943</citedby><cites>FETCH-LOGICAL-c388t-726dbf50c128ea40b3d8eacebc68b5ca023d2d289893eae7e6a14c7ce3bcbc943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(86)90723-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3720830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uematsu, Toshihiko</creatorcontrib><creatorcontrib>Cook, Nigel S.</creatorcontrib><creatorcontrib>Hof, Robert P.</creatorcontrib><creatorcontrib>Vozeh, Samuel</creatorcontrib><creatorcontrib>Follath, Ferenc</creatorcontrib><title>Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The (+)-enantiomer of the dihydropydine 202–791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (-)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (-)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therfore be considered when the potential therapeutic uses of calcium channel activators are discussed.</description><subject>Animals</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Ca channel activator</subject><subject>Ca channel blocker</subject><subject>calcium</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary ligation-reperfusion arrhythmias</subject><subject>dihydropyridine</subject><subject>heart</subject><subject>Langendorff perfused rat heart</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stereoisomerism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuqFDEQhoMox3H0DRSyEgVbc-nuJJsDcjhe4IAbXYd0Uk1HupMxyYz0znfQJ_RJzDjDLHVVVNVf9Rf1IfSUkteU0P4NIbRtmFLqhexfKiIYb7p7aEOlUA0RlN1Hm4vkIXqU81dCSKdYd4WuuGBEcrJBv27HEWzJOI64TIAhmFB8XCBdSs5Pq0txtybvfKg5JH8wxR8AM8J-__gpFMUxYBtDScYWP_uyvqppisGkFY9z_I5NcNhnO8HiTZNgNgUcNilNa5lqKWMfcDIFT2BSeYwejGbO8OQct-jLu9vPNx-au0_vP968vWssl7I0gvVuGDtiKZNgWjJwV6OFwfZy6KwhjDvmmFRScTAgoDe0tcICH-xgVcu36Plp7y7Fb3vIRS_1RphnEyDusxa9VKLl_L9C2vaCH222qD0JbYo5Jxj1LvmlfkFToo_U9BGJPiLRstd_qemujj07798PC7jL0BlT7V-f-lC_cfCQdLYeggXnU6WnXfT_NvgDsbeqxA</recordid><startdate>19860429</startdate><enddate>19860429</enddate><creator>Uematsu, Toshihiko</creator><creator>Cook, Nigel S.</creator><creator>Hof, Robert P.</creator><creator>Vozeh, Samuel</creator><creator>Follath, Ferenc</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19860429</creationdate><title>Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart</title><author>Uematsu, Toshihiko ; 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Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (-)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therfore be considered when the potential therapeutic uses of calcium channel activators are discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3720830</pmid><doi>10.1016/0014-2999(86)90723-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1986-04, Vol.123 (3), p.455-458 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Ca channel activator Ca channel blocker calcium Coronary Circulation - drug effects Coronary Disease - complications Coronary Disease - physiopathology Coronary ligation-reperfusion arrhythmias dihydropyridine heart Langendorff perfused rat heart Male Myocardial Contraction - drug effects Rats Rats, Inbred Strains Stereoisomerism |
| title | Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart |
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