Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart

The (+)-enantiomer of the dihydropydine 202–791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (-)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the my...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1986-04, Vol.123 (3), p.455-458
Hauptverfasser:	Uematsu, Toshihiko, Cook, Nigel S., Hof, Robert P., Vozeh, Samuel, Follath, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Ca channel activator Ca channel blocker calcium Coronary Circulation - drug effects Coronary Disease - complications Coronary Disease - physiopathology Coronary ligation-reperfusion arrhythmias dihydropyridine heart Langendorff perfused rat heart Male Myocardial Contraction - drug effects Rats Rats, Inbred Strains Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The (+)-enantiomer of the dihydropydine 202–791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (-)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (-)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therfore be considered when the potential therapeutic uses of calcium channel activators are discussed.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(86)90723-5