Spontaneous renal lesions in CD-1 and B6C3F1 mice
Incidence and pathology of naturally occurring renal lesions in CD-1 and B6C3F1 mice are evaluated, tabulated, and discussed. In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1994-08, Vol.46 (3), p.189-198 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
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| creator | Chandra, M. Frith, C.H. |
| description | Incidence and pathology of naturally occurring renal lesions in CD-1 and B6C3F1 mice are evaluated, tabulated, and discussed. In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular mineralization (12.8 %), cortical cysts (8.2 %), hydronephrosis (6.7 %), tubular dilatation (5.9 %), and tubular degeneration/regeneration (4.7 %). Cortical epithelial origin renal cell carcinomas were observed in one male (0.13 %) and one female mice (0.13 %). In B6C3F1 mice, most commonly occurring non-neoplastic renal lesion was mononuclear cell infiltration (29.8 %) followed by tubular mineralization (11.3 %), interstitial nephritis (6.8 %), tubular vacuolization (4.5 %), tubular degeneration/regeneration (2.5 %), and cortical cysts (1.3 %). Cortical cell adenoma was the only primary renal neoplasm which was observed in one female mice (0.16 %). In both strains, other renal lesions were less frequent. |
| doi_str_mv | 10.1016/S0940-2993(11)80080-1 |
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In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular mineralization (12.8 %), cortical cysts (8.2 %), hydronephrosis (6.7 %), tubular dilatation (5.9 %), and tubular degeneration/regeneration (4.7 %). Cortical epithelial origin renal cell carcinomas were observed in one male (0.13 %) and one female mice (0.13 %). In B6C3F1 mice, most commonly occurring non-neoplastic renal lesion was mononuclear cell infiltration (29.8 %) followed by tubular mineralization (11.3 %), interstitial nephritis (6.8 %), tubular vacuolization (4.5 %), tubular degeneration/regeneration (2.5 %), and cortical cysts (1.3 %). Cortical cell adenoma was the only primary renal neoplasm which was observed in one female mice (0.16 %). In both strains, other renal lesions were less frequent.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/S0940-2993(11)80080-1</identifier><identifier>PMID: 8000238</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adenoma - pathology ; Adenoma - veterinary ; Amyloidosis, renal ; Animals ; B6C3F1 mice ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - veterinary ; CD-1 mice ; Female ; Hydronephrosis ; Kidney ; Kidney Diseases - pathology ; Kidney Diseases - veterinary ; Kidney Neoplasms - pathology ; Kidney Neoplasms - veterinary ; Male ; Mice ; Mice, Inbred Strains ; Mononuclear cell infiltration, Kidney ; Nephritis, interstitial ; Renal lesions ; Rodent Diseases - pathology ; Tubular cysts ; Tubular mineralization</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 1994-08, Vol.46 (3), p.189-198</ispartof><rights>1994 Gustav Fischer Verlag Jena GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-254e44e7dba63cef1eb7f7cfde353405a051d6351a56008d783bcafea0a4bec43</citedby><cites>FETCH-LOGICAL-c360t-254e44e7dba63cef1eb7f7cfde353405a051d6351a56008d783bcafea0a4bec43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0940-2993(11)80080-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8000238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandra, M.</creatorcontrib><creatorcontrib>Frith, C.H.</creatorcontrib><title>Spontaneous renal lesions in CD-1 and B6C3F1 mice</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Incidence and pathology of naturally occurring renal lesions in CD-1 and B6C3F1 mice are evaluated, tabulated, and discussed. In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular mineralization (12.8 %), cortical cysts (8.2 %), hydronephrosis (6.7 %), tubular dilatation (5.9 %), and tubular degeneration/regeneration (4.7 %). Cortical epithelial origin renal cell carcinomas were observed in one male (0.13 %) and one female mice (0.13 %). In B6C3F1 mice, most commonly occurring non-neoplastic renal lesion was mononuclear cell infiltration (29.8 %) followed by tubular mineralization (11.3 %), interstitial nephritis (6.8 %), tubular vacuolization (4.5 %), tubular degeneration/regeneration (2.5 %), and cortical cysts (1.3 %). Cortical cell adenoma was the only primary renal neoplasm which was observed in one female mice (0.16 %). In both strains, other renal lesions were less frequent.</description><subject>Adenoma - pathology</subject><subject>Adenoma - veterinary</subject><subject>Amyloidosis, renal</subject><subject>Animals</subject><subject>B6C3F1 mice</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - veterinary</subject><subject>CD-1 mice</subject><subject>Female</subject><subject>Hydronephrosis</subject><subject>Kidney</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - veterinary</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - veterinary</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mononuclear cell infiltration, Kidney</subject><subject>Nephritis, interstitial</subject><subject>Renal lesions</subject><subject>Rodent Diseases - pathology</subject><subject>Tubular cysts</subject><subject>Tubular mineralization</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQhS0EKqXwEyrlhOAQmImXJCcEYZUqcSicLceeSEZZSpwi8e9JF_XKaQ7vvXkzH2NzhBsEVLdLyAXESZ7zK8TrDCCDGI_YFBVmMQrOj9n0YDllZyF8ASSQS5ywyWiHhGdThstV1w6mpW4dop5aU0c1Bd-1IfJtVDzGGJnWRQ-q4M8YNd7SOTupTB3oYj9n7PP56aN4jRfvL2_F_SK2XMEQJ1KQEJS60ihuqUIq0yq1lSMuuQBpQKJTXKKRarzdpRkvranIgBElWcFn7HK3d9V332sKg258sFTXu2N1qrJcJuMXMyZ3Rtt3IfRU6VXvG9P_agS9QaW3qPSGg0bUW1Qax9x8X7AuG3KH1J7NqN_tdBq__PHU62A9tZac78kO2nX-n4Y_vll2Gg</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Chandra, M.</creator><creator>Frith, C.H.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>Spontaneous renal lesions in CD-1 and B6C3F1 mice</title><author>Chandra, M. ; Frith, C.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-254e44e7dba63cef1eb7f7cfde353405a051d6351a56008d783bcafea0a4bec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenoma - pathology</topic><topic>Adenoma - veterinary</topic><topic>Amyloidosis, renal</topic><topic>Animals</topic><topic>B6C3F1 mice</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - veterinary</topic><topic>CD-1 mice</topic><topic>Female</topic><topic>Hydronephrosis</topic><topic>Kidney</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - veterinary</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - veterinary</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mononuclear cell infiltration, Kidney</topic><topic>Nephritis, interstitial</topic><topic>Renal lesions</topic><topic>Rodent Diseases - pathology</topic><topic>Tubular cysts</topic><topic>Tubular mineralization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chandra, M.</creatorcontrib><creatorcontrib>Frith, C.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandra, M.</au><au>Frith, C.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous renal lesions in CD-1 and B6C3F1 mice</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>46</volume><issue>3</issue><spage>189</spage><epage>198</epage><pages>189-198</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Incidence and pathology of naturally occurring renal lesions in CD-1 and B6C3F1 mice are evaluated, tabulated, and discussed. In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular mineralization (12.8 %), cortical cysts (8.2 %), hydronephrosis (6.7 %), tubular dilatation (5.9 %), and tubular degeneration/regeneration (4.7 %). Cortical epithelial origin renal cell carcinomas were observed in one male (0.13 %) and one female mice (0.13 %). In B6C3F1 mice, most commonly occurring non-neoplastic renal lesion was mononuclear cell infiltration (29.8 %) followed by tubular mineralization (11.3 %), interstitial nephritis (6.8 %), tubular vacuolization (4.5 %), tubular degeneration/regeneration (2.5 %), and cortical cysts (1.3 %). Cortical cell adenoma was the only primary renal neoplasm which was observed in one female mice (0.16 %). In both strains, other renal lesions were less frequent.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>8000238</pmid><doi>10.1016/S0940-2993(11)80080-1</doi><tpages>10</tpages></addata></record> |
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| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 1994-08, Vol.46 (3), p.189-198 |
| issn | 0940-2993 1618-1433 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenoma - pathology Adenoma - veterinary Amyloidosis, renal Animals B6C3F1 mice Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - veterinary CD-1 mice Female Hydronephrosis Kidney Kidney Diseases - pathology Kidney Diseases - veterinary Kidney Neoplasms - pathology Kidney Neoplasms - veterinary Male Mice Mice, Inbred Strains Mononuclear cell infiltration, Kidney Nephritis, interstitial Renal lesions Rodent Diseases - pathology Tubular cysts Tubular mineralization |
| title | Spontaneous renal lesions in CD-1 and B6C3F1 mice |
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