Spontaneous renal lesions in CD-1 and B6C3F1 mice

Incidence and pathology of naturally occurring renal lesions in CD-1 and B6C3F1 mice are evaluated, tabulated, and discussed. In CD-1 mice, most frequent non-neoplastic renal lesion was interstitial nephritis (72.6 %) followed by amyloidosis (40.6 %), mononuclear cell infiltration (23.6 %), tubular mineralization (12.8 %), cortical cysts (8.2 %), hydronephrosis (6.7 %), tubular dilatation (5.9 %), and tubular degeneration/regeneration (4.7 %). Cortical epithelial origin renal cell carcinomas were observed in one male (0.13 %) and one female mice (0.13 %). In B6C3F1 mice, most commonly occurring non-neoplastic renal lesion was mononuclear cell infiltration (29.8 %) followed by tubular mineralization (11.3 %), interstitial nephritis (6.8 %), tubular vacuolization (4.5 %), tubular degeneration/regeneration (2.5 %), and cortical cysts (1.3 %). Cortical cell adenoma was the only primary renal neoplasm which was observed in one female mice (0.16 %). In both strains, other renal lesions were less frequent.