Studies on the Metabolites of Penicillium diversum var. aureum. I

Three new trihydroxytetralones (1, 2 and 3) have been isolated from the culture broth of P.diversum var. aureum together with three known naphthalenones (sclerone, isosclerone and juglone). The structure of 1 was determined on the basis of its chemical properties and spectroscopic analyses of the mo...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1986/04/25, Vol.34(4), pp.1497-1500
Hauptverfasser:	FUJIMOTO, YASUO, YOKOYAMA, EIZO, TAKAHASHI, TATSUYUKI, UZAWA, JUN, MOROOKA, NOBUHISA, TSUNODA, HIROSHI, TATSUNO, TAKASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - pharmacology Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Medical sciences metabolite antitumor activity Penicillium - metabolism Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Sarcoma, Experimental - pathology
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Beschreibung
Zusammenfassung:	Three new trihydroxytetralones (1, 2 and 3) have been isolated from the culture broth of P.diversum var. aureum together with three known naphthalenones (sclerone, isosclerone and juglone). The structure of 1 was determined on the basis of its chemical properties and spectroscopic analyses of the monomethyl ether (4) and dimethyl ether (5).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.34.1497