Immunologic alterations in xeroderma pigmentosum patients
Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The poss...
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| Veröffentlicht in: | Cancer 1986-07, Vol.58 (2), p.219-221 |
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| container_issue | 2 |
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| container_title | Cancer |
| container_volume | 58 |
| creator | Wysenbeek, Arjeh J. Weiss, Haya Duczyminer‐Kahana, Malka Grunwald, Marcello H. Pick, Albert I. |
| description | Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986. |
| doi_str_mv | 10.1002/1097-0142(19860715)58:2<219::AID-CNCR2820580203>3.0.CO;2-A |
| format | Article |
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In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19860715)58:2<219::AID-CNCR2820580203>3.0.CO;2-A</identifier><identifier>PMID: 2941138</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Dermatology ; Female ; Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue ; Humans ; Hypersensitivity, Delayed ; Immunity, Cellular ; Lymphocyte Activation ; Male ; Medical sciences ; Middle Aged ; T-Lymphocytes, Helper-Inducer - immunology ; Xeroderma Pigmentosum - immunology</subject><ispartof>Cancer, 1986-07, Vol.58 (2), p.219-221</ispartof><rights>Copyright © 1986 American Cancer Society</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4103-2bd959a0b3607ff46f34c03bd0617cd78a16d0132a7a85a1bf3dfcdd5a7dd7713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8739726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2941138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wysenbeek, Arjeh J.</creatorcontrib><creatorcontrib>Weiss, Haya</creatorcontrib><creatorcontrib>Duczyminer‐Kahana, Malka</creatorcontrib><creatorcontrib>Grunwald, Marcello H.</creatorcontrib><creatorcontrib>Pick, Albert I.</creatorcontrib><title>Immunologic alterations in xeroderma pigmentosum patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatology</subject><subject>Female</subject><subject>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed</subject><subject>Immunity, Cellular</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Xeroderma Pigmentosum - immunology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1rFDEUhoNY6lr9CcJciOjFrCfJZJKsImynVRdKF4qCeHPIJJkyMh9rsoPtv2-WXRf0QvAqCe-Tw3seQs4pzCkAe0tByxxowV5TrUqQVLwRasHeM6oXi-XqIq-uqxumGAgFDPgHPod5tX7H8uUjMjt-fkxmAKByUfBvT8jTGH-kp2SCn5JTpgtKuZoRver7aRi78ba1mem2PphtOw4xa4fszofR-dCbbNPe9n7YjnHqs00C0j0-IyeN6aJ_fjjPyNePl1-qz_nV-tOqWl7ltqDAc1Y7LbSBmqdFmqYoG15Y4LWDkkrrpDK0dEA5M9IoYWjdcNdY54SRzklJ-Rl5tZ-7CePPycct9m20vuvM4McpoiyV5pLJBH7fgzaMMQbf4Ca0vQn3SAF3XnGnBndq8LdXFAoZJq-IySv-6RU5AlbrBCzT8BeHFlPde3ccfRCZ8peH3ERruiaYwbbxiCnJtWRlwvwe-9V2_v6_Cv6z318JfwB6kaIc</recordid><startdate>19860715</startdate><enddate>19860715</enddate><creator>Wysenbeek, Arjeh J.</creator><creator>Weiss, Haya</creator><creator>Duczyminer‐Kahana, Malka</creator><creator>Grunwald, Marcello H.</creator><creator>Pick, Albert I.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860715</creationdate><title>Immunologic alterations in xeroderma pigmentosum patients</title><author>Wysenbeek, Arjeh J. ; Weiss, Haya ; Duczyminer‐Kahana, Malka ; Grunwald, Marcello H. ; Pick, Albert I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4103-2bd959a0b3607ff46f34c03bd0617cd78a16d0132a7a85a1bf3dfcdd5a7dd7713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatology</topic><topic>Female</topic><topic>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed</topic><topic>Immunity, Cellular</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Xeroderma Pigmentosum - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wysenbeek, Arjeh J.</creatorcontrib><creatorcontrib>Weiss, Haya</creatorcontrib><creatorcontrib>Duczyminer‐Kahana, Malka</creatorcontrib><creatorcontrib>Grunwald, Marcello H.</creatorcontrib><creatorcontrib>Pick, Albert I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wysenbeek, Arjeh J.</au><au>Weiss, Haya</au><au>Duczyminer‐Kahana, Malka</au><au>Grunwald, Marcello H.</au><au>Pick, Albert I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunologic alterations in xeroderma pigmentosum patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1986-07-15</date><risdate>1986</risdate><volume>58</volume><issue>2</issue><spage>219</spage><epage>221</epage><pages>219-221</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2941138</pmid><doi>10.1002/1097-0142(19860715)58:2<219::AID-CNCR2820580203>3.0.CO;2-A</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1986-07, Vol.58 (2), p.219-221 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Child Dermatology Female Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Hypersensitivity, Delayed Immunity, Cellular Lymphocyte Activation Male Medical sciences Middle Aged T-Lymphocytes, Helper-Inducer - immunology Xeroderma Pigmentosum - immunology |
| title | Immunologic alterations in xeroderma pigmentosum patients |
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