Immunologic alterations in xeroderma pigmentosum patients

Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The poss...

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Veröffentlicht in:	Cancer 1986-07, Vol.58 (2), p.219-221
Hauptverfasser:	Wysenbeek, Arjeh J., Weiss, Haya, Duczyminer‐Kahana, Malka, Grunwald, Marcello H., Pick, Albert I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Child Dermatology Female Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Hypersensitivity, Delayed Immunity, Cellular Lymphocyte Activation Male Medical sciences Middle Aged T-Lymphocytes, Helper-Inducer - immunology Xeroderma Pigmentosum - immunology
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Zusammenfassung:	Nine xeroderma pigmentosum (XP) patients were investigated. In comparison to a normal control group the XP patients had a reduced OKT‐4 lymphocyte subpopulation, reduced response of lymphocytes to phytohemagglutinin in autologous serum, and diminished delayed hypersensitivity skin reaction. The possible contribution of ultraviolet irradiation to the observed immunologic alterations, and the link of these alterations to the susceptibility of patients for malignant transformation is discussed. Cancer 58:219–221, 1986.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(19860715)58:2<219::AID-CNCR2820580203>3.0.CO;2-A