Importance of Parallel Vectors and "Hydrophobic Collapse" of the Aligned Aromatic Rings: Discovery of a Potent Substance P Antagonist

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Veröffentlicht in:	Journal of medicinal chemistry 1994-12, Vol.37 (25), p.4263-4266
Hauptverfasser:	Desai, Manoj C, Vincent, Lawrence A, Rizzi, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical Phenomena Chemistry, Physical Humans Medical sciences Miscellaneous Models, Molecular Molecular Conformation Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperidines - chemistry Piperidines - metabolism Receptors, Neurokinin-1 - metabolism Structure-Activity Relationship Substance P - antagonists & inhibitors
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