The role of N-6-isopentenyl adenine in tumor cell growth

The role of N-6-isopentenyl adenine in tumor cell growth

When cell extracts from Ehrlich ascites tumor cells were assayed for isopentenyl adenine content and correlation with cell growth stage by radioimmunoassay, concentrations of low statastical significance were obtained. High performance liquid chromatographic analysis of cell extracts showed undetect...

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Veröffentlicht in:Biochem. Biophys. Res. Commun.; (United States) 1986-05, Vol.137 (1), p.208-214
Hauptverfasser: Lee Adair, W., Brennan, Susan L.
Format: Artikel
Sprache:eng
Schlagworte:
550201 - Biochemistry- Tracer Techniques
Adenine - analogs & derivatives
Adenine - physiology
ADENINES
AMINES
ANIMAL CELLS
Animals
ANTIMETABOLITES
Applied sciences
AROMATICS
ASCITES TUMOR CELLS
AZAARENES
BASIC BIOLOGICAL SCIENCES
Carcinoma, Ehrlich Tumor - metabolism
Cell Cycle - drug effects
CHROMATOGRAPHY
DATA
DRUGS
Exact sciences and technology
EXPERIMENTAL DATA
GROWTH
HETEROCYCLIC COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INFORMATION
Isopentenyladenosine
ISOTOPE APPLICATIONS
LIQUID COLUMN CHROMATOGRAPHY
Lovastatin
METABOLITES
Mice
Naphthalenes - pharmacology
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
Other techniques and industries
PURINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
SEPARATION PROCESSES
TRACER TECHNIQUES
TUMOR CELLS
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Zusammenfassung:When cell extracts from Ehrlich ascites tumor cells were assayed for isopentenyl adenine content and correlation with cell growth stage by radioimmunoassay, concentrations of low statastical significance were obtained. High performance liquid chromatographic analysis of cell extracts showed undetectable levels of isopentenyl adenine or 8-hydroxy-isopentenyl adenine, a known metabolite. Thus these substances do not seem to be required for cell division in Ehrlich ascites tumor cells.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(86)91197-6