Serum fatty acid profiles in cystic fibrosis patients and their parents

Serum fatty acid profiles in cystic fibrosis patients and their parents

Fatty acid compositions of the major serum lipid classes from 43 cystic fibrosis (CF) homozygotes (CF patients), 36 obligate heterozygotes (parents of CF patients) and 34 controls were determined by capillary gas chromatography. Fatty acid compositions of the homozygote CF patients were skewed in th...

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Veröffentlicht in:Lipids 1994-08, Vol.29 (8), p.569-575
Hauptverfasser: Christophe, A. B., Warwick, W. J., Holman, R. T.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Child
Child, Preschool
Cystic Fibrosis - blood
Cystic Fibrosis - genetics
Fatty Acids - blood
Female
Heterozygote
Homozygote
Humans
Linoleic Acid
Linoleic Acids - blood
Male
Parents
Phospholipids - blood
Phospholipids - chemistry
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Zusammenfassung:Fatty acid compositions of the major serum lipid classes from 43 cystic fibrosis (CF) homozygotes (CF patients), 36 obligate heterozygotes (parents of CF patients) and 34 controls were determined by capillary gas chromatography. Fatty acid compositions of the homozygote CF patients were skewed in the direction of relative essential fatty acid deficiency in comparison with the controls. Less pronounced, but similar deviations from normal, were observed in the heterozygotes. Homozygotes with normal fatty acid compositions and heterozygotes with considerably disturbed fatty acid profiles were found.
ISSN:0024-4201
1558-9307
DOI:10.1007/BF02536629