Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland
Ectopic expression of Wnt-1 in the mammary epithelium causes hyperplasias and increases the frequency of tumour formation. Other members of the Wnt gene family are naturally expressed in the breast and are throught to be involved in controlling mammary gland development. Using Northern and in-situ h...
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Veröffentlicht in: | Differentiation (London) 1994-09, Vol.57 (3), p.205-214 |
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Sprache: | eng |
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Zusammenfassung: | Ectopic expression of
Wnt-1 in the mammary epithelium causes hyperplasias and increases the frequency of tumour formation. Other members of the
Wnt gene family are naturally expressed in the breast and are throught to be involved in controlling mammary gland development. Using Northern and in-situ hybridisation, differential expression of
Wnt-2,
Wnt-4,
Wnt-5a,
Wnt-5b,
Wnt-6 and
Wnt-7b in epithelial and mesenchymal compartments was observed. Complex patterns of
Wnt expression were found during the ductal, lobulo-alveolar and involution phases of development. Finally,
Wnt-2,
Wnt-4 and
Wnt-5b were shown to be regulated by ovarian hormones. These results suggest that
Wnt genes have non-redundant roles in breast development and may be involved in the hormonal regulation of mammary growth. |
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ISSN: | 0301-4681 1432-0436 |
DOI: | 10.1046/j.1432-0436.1994.5730205.x |