High frequencies of α-thalassaemia are the result of natural selection by malaria
The frequency of α + -thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high f...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1986-06, Vol.321 (6072), p.744-750 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 750 |
|---|---|
| container_issue | 6072 |
| container_start_page | 744 |
| container_title | Nature (London) |
| container_volume | 321 |
| creator | Flint, J. Hill, A. V. S. Bowden, D. K. Oppenheimer, S. J. Sill, P. R. Serjeantson, S. W. Bana-Koiri, J. Bhatia, K. Alpers, M. P. Boyce, A. J. Weatherall, D. J. Clegg, J. B. |
| description | The frequency of
α
+
-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world. |
| doi_str_mv | 10.1038/321744a0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76866843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14626293</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2580-700a0bdb21f8aa585daa03ba7f832c4b1066e769590c87884c620aea74ec59da3</originalsourceid><addsrcrecordid>eNqFkM1Kw0AUhQdRaq2CLyDMSnQRvZOZzEyXUtQKBUF0HW4mN21KfnQmWfSxfBGfyZRWNy5c3cX5zuHyMXYu4EaAtLcyFkYphAM2FsroSGlrDtkYILYRWKmP2UkIawBIBm7ERtIIabUcs5d5uVzxwtNHT40rKfC24F-fUbfCCkNAqkvk6Il3K-KeQl91W6LBrvdY8UAVua5sG55teD1UfImn7KjAKtDZ_k7Y28P962weLZ4fn2Z3i8jFiYXIACBkeRaLwiImNskRQWZoCitjpzIBWpPR02QKzhprldMxIKFR5JJpjnLCLne7774dvg9dWpfBUVVhQ20fUqOt1lbJf0GhdKzj6Ra82oHOtyF4KtJ3X9boN6mAdOs5_fE8oBf7zT6rKf8F92KH_HqXhyFpluTTddv7ZvDxd-sb7SaE9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14626293</pqid></control><display><type>article</type><title>High frequencies of α-thalassaemia are the result of natural selection by malaria</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Flint, J. ; Hill, A. V. S. ; Bowden, D. K. ; Oppenheimer, S. J. ; Sill, P. R. ; Serjeantson, S. W. ; Bana-Koiri, J. ; Bhatia, K. ; Alpers, M. P. ; Boyce, A. J. ; Weatherall, D. J. ; Clegg, J. B.</creator><creatorcontrib>Flint, J. ; Hill, A. V. S. ; Bowden, D. K. ; Oppenheimer, S. J. ; Sill, P. R. ; Serjeantson, S. W. ; Bana-Koiri, J. ; Bhatia, K. ; Alpers, M. P. ; Boyce, A. J. ; Weatherall, D. J. ; Clegg, J. B.</creatorcontrib><description>The frequency of
α
+
-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/321744a0</identifier><identifier>PMID: 3713863</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Altitude ; Gene Frequency ; Genotype ; Humanities and Social Sciences ; Humans ; Malaria - complications ; Melanesia ; multidisciplinary ; New Guinea ; Science ; Science (multidisciplinary) ; Selection, Genetic ; Thalassemia - complications ; Thalassemia - genetics</subject><ispartof>Nature (London), 1986-06, Vol.321 (6072), p.744-750</ispartof><rights>Springer Nature Limited 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2580-700a0bdb21f8aa585daa03ba7f832c4b1066e769590c87884c620aea74ec59da3</citedby><cites>FETCH-LOGICAL-c2580-700a0bdb21f8aa585daa03ba7f832c4b1066e769590c87884c620aea74ec59da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/321744a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/321744a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3713863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flint, J.</creatorcontrib><creatorcontrib>Hill, A. V. S.</creatorcontrib><creatorcontrib>Bowden, D. K.</creatorcontrib><creatorcontrib>Oppenheimer, S. J.</creatorcontrib><creatorcontrib>Sill, P. R.</creatorcontrib><creatorcontrib>Serjeantson, S. W.</creatorcontrib><creatorcontrib>Bana-Koiri, J.</creatorcontrib><creatorcontrib>Bhatia, K.</creatorcontrib><creatorcontrib>Alpers, M. P.</creatorcontrib><creatorcontrib>Boyce, A. J.</creatorcontrib><creatorcontrib>Weatherall, D. J.</creatorcontrib><creatorcontrib>Clegg, J. B.</creatorcontrib><title>High frequencies of α-thalassaemia are the result of natural selection by malaria</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The frequency of
α
+
-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.</description><subject>Altitude</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Malaria - complications</subject><subject>Melanesia</subject><subject>multidisciplinary</subject><subject>New Guinea</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Selection, Genetic</subject><subject>Thalassemia - complications</subject><subject>Thalassemia - genetics</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AUhQdRaq2CLyDMSnQRvZOZzEyXUtQKBUF0HW4mN21KfnQmWfSxfBGfyZRWNy5c3cX5zuHyMXYu4EaAtLcyFkYphAM2FsroSGlrDtkYILYRWKmP2UkIawBIBm7ERtIIabUcs5d5uVzxwtNHT40rKfC24F-fUbfCCkNAqkvk6Il3K-KeQl91W6LBrvdY8UAVua5sG55teD1UfImn7KjAKtDZ_k7Y28P962weLZ4fn2Z3i8jFiYXIACBkeRaLwiImNskRQWZoCitjpzIBWpPR02QKzhprldMxIKFR5JJpjnLCLne7774dvg9dWpfBUVVhQ20fUqOt1lbJf0GhdKzj6Ra82oHOtyF4KtJ3X9boN6mAdOs5_fE8oBf7zT6rKf8F92KH_HqXhyFpluTTddv7ZvDxd-sb7SaE9w</recordid><startdate>19860619</startdate><enddate>19860619</enddate><creator>Flint, J.</creator><creator>Hill, A. V. S.</creator><creator>Bowden, D. K.</creator><creator>Oppenheimer, S. J.</creator><creator>Sill, P. R.</creator><creator>Serjeantson, S. W.</creator><creator>Bana-Koiri, J.</creator><creator>Bhatia, K.</creator><creator>Alpers, M. P.</creator><creator>Boyce, A. J.</creator><creator>Weatherall, D. J.</creator><creator>Clegg, J. B.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19860619</creationdate><title>High frequencies of α-thalassaemia are the result of natural selection by malaria</title><author>Flint, J. ; Hill, A. V. S. ; Bowden, D. K. ; Oppenheimer, S. J. ; Sill, P. R. ; Serjeantson, S. W. ; Bana-Koiri, J. ; Bhatia, K. ; Alpers, M. P. ; Boyce, A. J. ; Weatherall, D. J. ; Clegg, J. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2580-700a0bdb21f8aa585daa03ba7f832c4b1066e769590c87884c620aea74ec59da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Altitude</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Malaria - complications</topic><topic>Melanesia</topic><topic>multidisciplinary</topic><topic>New Guinea</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Selection, Genetic</topic><topic>Thalassemia - complications</topic><topic>Thalassemia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flint, J.</creatorcontrib><creatorcontrib>Hill, A. V. S.</creatorcontrib><creatorcontrib>Bowden, D. K.</creatorcontrib><creatorcontrib>Oppenheimer, S. J.</creatorcontrib><creatorcontrib>Sill, P. R.</creatorcontrib><creatorcontrib>Serjeantson, S. W.</creatorcontrib><creatorcontrib>Bana-Koiri, J.</creatorcontrib><creatorcontrib>Bhatia, K.</creatorcontrib><creatorcontrib>Alpers, M. P.</creatorcontrib><creatorcontrib>Boyce, A. J.</creatorcontrib><creatorcontrib>Weatherall, D. J.</creatorcontrib><creatorcontrib>Clegg, J. B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flint, J.</au><au>Hill, A. V. S.</au><au>Bowden, D. K.</au><au>Oppenheimer, S. J.</au><au>Sill, P. R.</au><au>Serjeantson, S. W.</au><au>Bana-Koiri, J.</au><au>Bhatia, K.</au><au>Alpers, M. P.</au><au>Boyce, A. J.</au><au>Weatherall, D. J.</au><au>Clegg, J. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High frequencies of α-thalassaemia are the result of natural selection by malaria</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1986-06-19</date><risdate>1986</risdate><volume>321</volume><issue>6072</issue><spage>744</spage><epage>750</epage><pages>744-750</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>The frequency of
α
+
-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>3713863</pmid><doi>10.1038/321744a0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1986-06, Vol.321 (6072), p.744-750 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76866843 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Altitude Gene Frequency Genotype Humanities and Social Sciences Humans Malaria - complications Melanesia multidisciplinary New Guinea Science Science (multidisciplinary) Selection, Genetic Thalassemia - complications Thalassemia - genetics |
| title | High frequencies of α-thalassaemia are the result of natural selection by malaria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T16%3A47%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20frequencies%20of%20%CE%B1-thalassaemia%20are%20the%20result%20of%20natural%20selection%20by%20malaria&rft.jtitle=Nature%20(London)&rft.au=Flint,%20J.&rft.date=1986-06-19&rft.volume=321&rft.issue=6072&rft.spage=744&rft.epage=750&rft.pages=744-750&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/321744a0&rft_dat=%3Cproquest_cross%3E14626293%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14626293&rft_id=info:pmid/3713863&rfr_iscdi=true |