High frequencies of α -thalassaemia are the result of natural selection by malaria

High frequencies of α -thalassaemia are the result of natural selection by malaria

The frequency of α + -thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high f...

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Veröffentlicht in:Nature (London) 1986-06, Vol.321 (6072), p.744-750
Hauptverfasser: Flint, J, Hill, A. V. S, Bowden, D. K, Oppenheimer, S. J, Sill, P. R, Serjeantson, S. W, Bana-Koiri, J, Bhatia, K, Alpers, M. P, Boyce, A. J, Weatherall, D. J, Clegg, J. B
Format: Artikel
Sprache:eng
Schlagworte:
Altitude
Gene Frequency
Genotype
Humanities and Social Sciences
Humans
Malaria - complications
Melanesia
multidisciplinary
New Guinea
Science
Science (multidisciplinary)
Selection, Genetic
Thalassemia - complications
Thalassemia - genetics
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Zusammenfassung:The frequency of α + -thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.
ISSN:0028-0836
1476-4687
DOI:10.1038/321744a0