Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase
A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1994-07, Vol.12 (7), p.911-916 |
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| container_issue | 7 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 12 |
| creator | Van Overbeke, A. Baeyens, W. Van Den Bossche, W. Dewaele, C. |
| description | A reversed phase high-performance liquid chromatographic method has been developed for the determination of the
R- and
S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization. |
| doi_str_mv | 10.1016/0731-7085(94)E0012-P |
| format | Article |
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R- and
S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/0731-7085(94)E0012-P</identifier><identifier>PMID: 7981320</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>2-arylpropionic acids ; Amides - chemistry ; Amides - isolation & purification ; Analysis ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Benzoates ; Biological and medical sciences ; Cellulose - analogs & derivatives ; Chiral HPLC ; Chromatography, High Pressure Liquid ; General pharmacology ; Hydrogen-Ion Concentration ; Indicators and Reagents ; Medical sciences ; non steroidal anti-inflammatory drugs ; Pharmacology. Drug treatments ; Phenylpropionates - chemistry ; Phenylpropionates - isolation & purification ; Stereoisomerism ; tris(4-methylbenzoate)cellulose column</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1994-07, Vol.12 (7), p.911-916</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-50576082e9ae1a2ae9fba507ee327c68c19a46a03d751e7cc353ad1a8dd9caa13</citedby><cites>FETCH-LOGICAL-c386t-50576082e9ae1a2ae9fba507ee327c68c19a46a03d751e7cc353ad1a8dd9caa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0731708594E0012P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4208355$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7981320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Overbeke, A.</creatorcontrib><creatorcontrib>Baeyens, W.</creatorcontrib><creatorcontrib>Van Den Bossche, W.</creatorcontrib><creatorcontrib>Dewaele, C.</creatorcontrib><title>Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A reversed phase high-performance liquid chromatographic method has been developed for the determination of the
R- and
S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.</description><subject>2-arylpropionic acids</subject><subject>Amides - chemistry</subject><subject>Amides - isolation & purification</subject><subject>Analysis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Benzoates</subject><subject>Biological and medical sciences</subject><subject>Cellulose - analogs & derivatives</subject><subject>Chiral HPLC</subject><subject>Chromatography, High Pressure Liquid</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>non steroidal anti-inflammatory drugs</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylpropionates - chemistry</subject><subject>Phenylpropionates - isolation & purification</subject><subject>Stereoisomerism</subject><subject>tris(4-methylbenzoate)cellulose column</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFDEUhYMoY8_oP1DIQkQXpXlUHrUZkKbHERrshYK7cDu5xUTqZVLdMCv_uqnpppeuQu75zuFwCHnD2SfOuP7MjOSVYVZ9aOqPG8a4qHbPyIpbIyuh61_PyeqCvCTXOf9mjCne1FfkyjSWS8FW5O9mgGGOY48peppxggTlO9CxpdDHgDQU5VhuR8zLMReUigrSYzelcSpo8YGPIdP9I73fbde0uIF67LpDN2as9pAxUP8QE3Q0z0_xxU6nhyK8Ii9a6DK-Pr835Ofd5sf6vtp-__pt_WVbeWn1XCmmjGZWYAPIQQA27R4UM4hSGK-t5w3UGpgMRnE03kslIXCwITQegMsb8v6UW0r_OWCeXR_z0hEGHA_ZGW21sLUuYH0CfRpzTti6KcW-9HWcuWV3t4zqllFdU7un3d2u2N6e8w_7HsPFdB666O_OOmQPXZtg8DFfsFowK5Uq2O0Jw7LFMWJy2UccPIaY0M8ujPH_Pf4BnKag8Q</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Van Overbeke, A.</creator><creator>Baeyens, W.</creator><creator>Van Den Bossche, W.</creator><creator>Dewaele, C.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase</title><author>Van Overbeke, A. ; Baeyens, W. ; Van Den Bossche, W. ; Dewaele, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-50576082e9ae1a2ae9fba507ee327c68c19a46a03d751e7cc353ad1a8dd9caa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>2-arylpropionic acids</topic><topic>Amides - chemistry</topic><topic>Amides - isolation & purification</topic><topic>Analysis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Benzoates</topic><topic>Biological and medical sciences</topic><topic>Cellulose - analogs & derivatives</topic><topic>Chiral HPLC</topic><topic>Chromatography, High Pressure Liquid</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>non steroidal anti-inflammatory drugs</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylpropionates - chemistry</topic><topic>Phenylpropionates - isolation & purification</topic><topic>Stereoisomerism</topic><topic>tris(4-methylbenzoate)cellulose column</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Overbeke, A.</creatorcontrib><creatorcontrib>Baeyens, W.</creatorcontrib><creatorcontrib>Van Den Bossche, W.</creatorcontrib><creatorcontrib>Dewaele, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Overbeke, A.</au><au>Baeyens, W.</au><au>Van Den Bossche, W.</au><au>Dewaele, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>12</volume><issue>7</issue><spage>911</spage><epage>916</epage><pages>911-916</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A reversed phase high-performance liquid chromatographic method has been developed for the determination of the
R- and
S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7981320</pmid><doi>10.1016/0731-7085(94)E0012-P</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1994-07, Vol.12 (7), p.911-916 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76862846 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2-arylpropionic acids Amides - chemistry Amides - isolation & purification Analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Benzoates Biological and medical sciences Cellulose - analogs & derivatives Chiral HPLC Chromatography, High Pressure Liquid General pharmacology Hydrogen-Ion Concentration Indicators and Reagents Medical sciences non steroidal anti-inflammatory drugs Pharmacology. Drug treatments Phenylpropionates - chemistry Phenylpropionates - isolation & purification Stereoisomerism tris(4-methylbenzoate)cellulose column |
| title | Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase |
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