Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase

A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1994-07, Vol.12 (7), p.911-916
Hauptverfasser:	Van Overbeke, A., Baeyens, W., Van Den Bossche, W., Dewaele, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-arylpropionic acids Amides - chemistry Amides - isolation & purification Analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Benzoates Biological and medical sciences Cellulose - analogs & derivatives Chiral HPLC Chromatography, High Pressure Liquid General pharmacology Hydrogen-Ion Concentration Indicators and Reagents Medical sciences non steroidal anti-inflammatory drugs Pharmacology. Drug treatments Phenylpropionates - chemistry Phenylpropionates - isolation & purification Stereoisomerism tris(4-methylbenzoate)cellulose column
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Zusammenfassung:	A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprofen could also be partially resolved into its enantiomers without prior derivatization.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/0731-7085(94)E0012-P