Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines
Murine macrophage-like cell lines were used to determine whether exogenously added prostaglandins and endogenous prostaglandins suppress interferon (IFN) synthesis in macrophagesThe amount of IFN produced by J774A.1 cells induced with bacterial lipopolysaccharide (LPS) was reduced by 0.1 and 1 [tM P...
Gespeichert in:
| Veröffentlicht in: | Immunobiology (1979) 1986-03, Vol.171 (1), p.155-163 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 163 |
|---|---|
| container_issue | 1 |
| container_start_page | 155 |
| container_title | Immunobiology (1979) |
| container_volume | 171 |
| creator | Salo, R.J. Maddux, Nanci L. Bleam, Diana K. |
| description | Murine macrophage-like cell lines were used to determine whether exogenously added prostaglandins and endogenous prostaglandins suppress interferon (IFN) synthesis in macrophagesThe amount of IFN produced by J774A.1 cells induced with bacterial lipopolysaccharide (LPS) was reduced by 0.1 and 1 [tM PGE, or PGE2These prostaglandins also inhibited Newcastle disease virus (NDV) induced IFN production, but only at a concentration of 1 μMThromboxane B
2 at 0.01 to 1 μM had no effect on IFN productionCells treated before, during, or before and during IFN synthesis with 0.15 to 4.8 μM indomethacin to inhibit prostaglandin synthesis did not increase IFN yieldsIndomethacin also had no effect on NDV-induced IFN production by P388D
1 and PU5-1.8 cells, and these cells remained nonresponsive to LPS for IFN productionThese results indicate that endogenous levels of cyclooxygenase-dependent metabolites of arachidonic acid do not regulate IFN synthesis in macrophages. |
| doi_str_mv | 10.1016/S0171-2985(86)80024-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76853428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0171298586800249</els_id><sourcerecordid>76853428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-eccc85d567e22546162b287129c5b9be68f39d5df599e153be4be8ca9bcf3bff3</originalsourceid><addsrcrecordid>eNqFkFtLAzEQhYMotV5-gpAn0YfVXDbZ5EmkeClUFLTPYTc70eg2W5Ot0H9vtMVXn2bgnJk58yF0QskFJVRePhNa0YJpJc6UPFeEsLLQO2hMVaUKziq9i8Z_ln10kNI7IVSzSo3QiJWMl7wco_mNc2AH3Dv8FPs01K9dHVofEu4DnoYBooOY2-d1GN4g-YR9wA-r6APgh9rGfvlWv0LR-Q_AE-g6PMtKOkJ7ru4SHG_rIZrf3rxM7ovZ4910cj0rLJdkKMBaq0QrZAWMiVJSyRqmKsq0FY1uQCrHdStaJ7QGKngDZQPK1rqxjjfO8UN0utm7jP3nCtJgFj7ZHKMO0K-SqaQSvGQqG8XGmBOnFMGZZfSLOq4NJeYHp_nFaX5YGSXNL06j89zJ9sCqWUD7N7Xll_WrjQ75yy8P0STrIVhofcxYTdv7fy58AzyyhYw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76853428</pqid></control><display><type>article</type><title>Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Salo, R.J. ; Maddux, Nanci L. ; Bleam, Diana K.</creator><creatorcontrib>Salo, R.J. ; Maddux, Nanci L. ; Bleam, Diana K.</creatorcontrib><description>Murine macrophage-like cell lines were used to determine whether exogenously added prostaglandins and endogenous prostaglandins suppress interferon (IFN) synthesis in macrophagesThe amount of IFN produced by J774A.1 cells induced with bacterial lipopolysaccharide (LPS) was reduced by 0.1 and 1 [tM PGE, or PGE2These prostaglandins also inhibited Newcastle disease virus (NDV) induced IFN production, but only at a concentration of 1 μMThromboxane B
2 at 0.01 to 1 μM had no effect on IFN productionCells treated before, during, or before and during IFN synthesis with 0.15 to 4.8 μM indomethacin to inhibit prostaglandin synthesis did not increase IFN yieldsIndomethacin also had no effect on NDV-induced IFN production by P388D
1 and PU5-1.8 cells, and these cells remained nonresponsive to LPS for IFN productionThese results indicate that endogenous levels of cyclooxygenase-dependent metabolites of arachidonic acid do not regulate IFN synthesis in macrophages.</description><identifier>ISSN: 0171-2985</identifier><identifier>EISSN: 1878-3279</identifier><identifier>DOI: 10.1016/S0171-2985(86)80024-9</identifier><identifier>PMID: 2423434</identifier><language>eng</language><publisher>Netherlands: Elsevier GmbH</publisher><subject>Alprostadil - pharmacology ; Animals ; Cell Line ; Dinoprostone ; Indomethacin - pharmacology ; Interferons - biosynthesis ; Interferons - pharmacology ; L Cells (Cell Line) - immunology ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Macrophages - immunology ; Mice ; Newcastle disease virus ; Prostaglandins E - pharmacology ; Thromboxane B2 - pharmacology ; Vesicular stomatitis Indiana virus - drug effects</subject><ispartof>Immunobiology (1979), 1986-03, Vol.171 (1), p.155-163</ispartof><rights>1985 Gustav Fischer Verlag · Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-eccc85d567e22546162b287129c5b9be68f39d5df599e153be4be8ca9bcf3bff3</citedby><cites>FETCH-LOGICAL-c360t-eccc85d567e22546162b287129c5b9be68f39d5df599e153be4be8ca9bcf3bff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0171-2985(86)80024-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2423434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salo, R.J.</creatorcontrib><creatorcontrib>Maddux, Nanci L.</creatorcontrib><creatorcontrib>Bleam, Diana K.</creatorcontrib><title>Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines</title><title>Immunobiology (1979)</title><addtitle>Immunobiology</addtitle><description>Murine macrophage-like cell lines were used to determine whether exogenously added prostaglandins and endogenous prostaglandins suppress interferon (IFN) synthesis in macrophagesThe amount of IFN produced by J774A.1 cells induced with bacterial lipopolysaccharide (LPS) was reduced by 0.1 and 1 [tM PGE, or PGE2These prostaglandins also inhibited Newcastle disease virus (NDV) induced IFN production, but only at a concentration of 1 μMThromboxane B
2 at 0.01 to 1 μM had no effect on IFN productionCells treated before, during, or before and during IFN synthesis with 0.15 to 4.8 μM indomethacin to inhibit prostaglandin synthesis did not increase IFN yieldsIndomethacin also had no effect on NDV-induced IFN production by P388D
1 and PU5-1.8 cells, and these cells remained nonresponsive to LPS for IFN productionThese results indicate that endogenous levels of cyclooxygenase-dependent metabolites of arachidonic acid do not regulate IFN synthesis in macrophages.</description><subject>Alprostadil - pharmacology</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Dinoprostone</subject><subject>Indomethacin - pharmacology</subject><subject>Interferons - biosynthesis</subject><subject>Interferons - pharmacology</subject><subject>L Cells (Cell Line) - immunology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Mice</subject><subject>Newcastle disease virus</subject><subject>Prostaglandins E - pharmacology</subject><subject>Thromboxane B2 - pharmacology</subject><subject>Vesicular stomatitis Indiana virus - drug effects</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLAzEQhYMotV5-gpAn0YfVXDbZ5EmkeClUFLTPYTc70eg2W5Ot0H9vtMVXn2bgnJk58yF0QskFJVRePhNa0YJpJc6UPFeEsLLQO2hMVaUKziq9i8Z_ln10kNI7IVSzSo3QiJWMl7wco_mNc2AH3Dv8FPs01K9dHVofEu4DnoYBooOY2-d1GN4g-YR9wA-r6APgh9rGfvlWv0LR-Q_AE-g6PMtKOkJ7ru4SHG_rIZrf3rxM7ovZ4910cj0rLJdkKMBaq0QrZAWMiVJSyRqmKsq0FY1uQCrHdStaJ7QGKngDZQPK1rqxjjfO8UN0utm7jP3nCtJgFj7ZHKMO0K-SqaQSvGQqG8XGmBOnFMGZZfSLOq4NJeYHp_nFaX5YGSXNL06j89zJ9sCqWUD7N7Xll_WrjQ75yy8P0STrIVhofcxYTdv7fy58AzyyhYw</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>Salo, R.J.</creator><creator>Maddux, Nanci L.</creator><creator>Bleam, Diana K.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860301</creationdate><title>Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines</title><author>Salo, R.J. ; Maddux, Nanci L. ; Bleam, Diana K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-eccc85d567e22546162b287129c5b9be68f39d5df599e153be4be8ca9bcf3bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Alprostadil - pharmacology</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Dinoprostone</topic><topic>Indomethacin - pharmacology</topic><topic>Interferons - biosynthesis</topic><topic>Interferons - pharmacology</topic><topic>L Cells (Cell Line) - immunology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Mice</topic><topic>Newcastle disease virus</topic><topic>Prostaglandins E - pharmacology</topic><topic>Thromboxane B2 - pharmacology</topic><topic>Vesicular stomatitis Indiana virus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salo, R.J.</creatorcontrib><creatorcontrib>Maddux, Nanci L.</creatorcontrib><creatorcontrib>Bleam, Diana K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunobiology (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salo, R.J.</au><au>Maddux, Nanci L.</au><au>Bleam, Diana K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>171</volume><issue>1</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><abstract>Murine macrophage-like cell lines were used to determine whether exogenously added prostaglandins and endogenous prostaglandins suppress interferon (IFN) synthesis in macrophagesThe amount of IFN produced by J774A.1 cells induced with bacterial lipopolysaccharide (LPS) was reduced by 0.1 and 1 [tM PGE, or PGE2These prostaglandins also inhibited Newcastle disease virus (NDV) induced IFN production, but only at a concentration of 1 μMThromboxane B
2 at 0.01 to 1 μM had no effect on IFN productionCells treated before, during, or before and during IFN synthesis with 0.15 to 4.8 μM indomethacin to inhibit prostaglandin synthesis did not increase IFN yieldsIndomethacin also had no effect on NDV-induced IFN production by P388D
1 and PU5-1.8 cells, and these cells remained nonresponsive to LPS for IFN productionThese results indicate that endogenous levels of cyclooxygenase-dependent metabolites of arachidonic acid do not regulate IFN synthesis in macrophages.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>2423434</pmid><doi>10.1016/S0171-2985(86)80024-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-2985 |
| ispartof | Immunobiology (1979), 1986-03, Vol.171 (1), p.155-163 |
| issn | 0171-2985 1878-3279 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76853428 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alprostadil - pharmacology Animals Cell Line Dinoprostone Indomethacin - pharmacology Interferons - biosynthesis Interferons - pharmacology L Cells (Cell Line) - immunology Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - immunology Mice Newcastle disease virus Prostaglandins E - pharmacology Thromboxane B2 - pharmacology Vesicular stomatitis Indiana virus - drug effects |
| title | Effect of Prostaglandins on Interferon Synthesis in Murine Macrophage-like Cell Lines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T22%3A09%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Prostaglandins%20on%20Interferon%20Synthesis%20in%20Murine%20Macrophage-like%20Cell%20Lines&rft.jtitle=Immunobiology%20(1979)&rft.au=Salo,%20R.J.&rft.date=1986-03-01&rft.volume=171&rft.issue=1&rft.spage=155&rft.epage=163&rft.pages=155-163&rft.issn=0171-2985&rft.eissn=1878-3279&rft_id=info:doi/10.1016/S0171-2985(86)80024-9&rft_dat=%3Cproquest_cross%3E76853428%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76853428&rft_id=info:pmid/2423434&rft_els_id=S0171298586800249&rfr_iscdi=true |