The electrophysiological effects of intravenous xamoterol in man

The electrophysiological effects of xamoterol were studied in ten patients with suspected coronary artery disease by intracardiac electrography. Sino-atrial and atrioventricular conduction times were both slightly shortened by 0.1 mg/kg of xamoterol. The atrioventricular nodal refractory periods wer...

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Veröffentlicht in:	European journal of clinical pharmacology 1986-01, Vol.29 (6), p.731-734
Hauptverfasser:	BOWES, R. J, GAUTAM, P. C, GRAHAM, D. R, HARLEY, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - pharmacology Adult Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Coronary Disease - physiopathology Electrocardiography Heart Conduction System - drug effects Heart Rate - drug effects Humans Injections, Intravenous Male Medical sciences Middle Aged Miscellaneous Pharmacology. Drug treatments Propanolamines - administration & dosage Propanolamines - pharmacology Xamoterol
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Zusammenfassung:	The electrophysiological effects of xamoterol were studied in ten patients with suspected coronary artery disease by intracardiac electrography. Sino-atrial and atrioventricular conduction times were both slightly shortened by 0.1 mg/kg of xamoterol. The atrioventricular nodal refractory periods were shortened without consistent change in atrial refractoriness. This dose raised mean blood pressure by only 3 mmHg and resting heart rate by only 4 beats/min. The effects suggest a beta 1 agonist activity closer to that of prenalterol than that of pindolol under conditions of rest.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00615969