Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution

Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution

An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a ma...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 1986-02, Vol.27 (2), p.235-238
Hauptverfasser: Hamacher, K, Coenen, H. H, Stocklin, G
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Phenomena
Chemistry
Deoxy Sugars - chemical synthesis
Deoxyglucose - analogs & derivatives
Deoxyglucose - chemical synthesis
Ethers
Fluorine
Fluorodeoxyglucose F18
Isotope Labeling
Polymers
Radioisotopes
Stereoisomerism
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Zusammenfassung:An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.
ISSN:0161-5505
1535-5667