Binding of [ 3H]nitrendipine to cardiac and cerebral membranes from normotensive and renal, deoxycorticosterone/NaCl and spontaneously hypertensive rats

The properties of [ 3H]nitrendipine binding to cardiac and cerebral membranes from normotensive Wistar-Kyoto (WKY) and renal (RHR), deoxycorticosterone/NaCl (DOCA-HR) and spontaneously hypertensive (SHR) rats were investigated. The maximal numbers of binding sites (B max) in the striatum, thalamus a...

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Veröffentlicht in:European journal of pharmacology 1986-04, Vol.123 (2), p.271-278
Hauptverfasser: Ishii, Kenji, Kano, Takashi, Ando, Joichi, Yoshida, Hiroshi
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Sprache:eng
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Zusammenfassung:The properties of [ 3H]nitrendipine binding to cardiac and cerebral membranes from normotensive Wistar-Kyoto (WKY) and renal (RHR), deoxycorticosterone/NaCl (DOCA-HR) and spontaneously hypertensive (SHR) rats were investigated. The maximal numbers of binding sites (B max) in the striatum, thalamus and hippocampus for SHR increased by 21.4–40.0, 28.1–40.4 and 21.4–34.1% of the numbers in WKY, but the apparent dissociation constants (K D) in the cerebral membranes differed very little between WKY and SHR. In the cardiac membranes, K D and B max values differed very little between WKY and SHR. In the RHR and DOCA-HR, the B max values in the striatum, thalamus and hippocampus were similar to those of WKY. These findings suggest that the increase in B max of [ 3H]nitrendipine in the striatum, thalamus and hippocampus of SHR may play a part in the development and maintenance of high blood pressure in SHR.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(86)90668-0