Application of Synthetic Hydrated Aluminum Silicates as Orally Administered Absorbents of Ammonium Ion

The adsorption of ammonium ion by three types of synthetic hydrated aluminum silicate (ZPC-10A, ZPC-50A and Molequlite 401) was studies to assess their possible utility as orally administered adsorbents for the treatment of uremia and ammoniemia. In vitro and preliminary in vivo studies suggest that...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1986/02/25, Vol.34(2), pp.806-812
Hauptverfasser:	ISHIBASHI, MUMIO, YOSHIOKA, SUMIE, SHIBAZAKI, TOSHIO, UCHIYAMA, MITSURU, WATANABE, TOSHIFUMI, KUROMATSU, YUZO, TAKAI, SHINJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Aluminum Silicates - pharmacology Animals Applied sciences Biological and medical sciences Dogs Exact sciences and technology Medical sciences orally administered adsorbent Other techniques and industries Pharmacology. Drug treatments Quaternary Ammonium Compounds - isolation & purification Urinary system
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Beschreibung
Zusammenfassung:	The adsorption of ammonium ion by three types of synthetic hydrated aluminum silicate (ZPC-10A, ZPC-50A and Molequlite 401) was studies to assess their possible utility as orally administered adsorbents for the treatment of uremia and ammoniemia. In vitro and preliminary in vivo studies suggest that ZPC-10A is promising as an adsorbent in terms of adsorption capacity, ion selectivity and resistance to acidity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.34.806