Macropore tissue ingrowth: a quantitative and qualitative study on hydroxyapatite ceramic

The aim of this study was to obtain more information about macropore tissue ingrowth into the pores of sintered hydroxyapatite implanted in the rat middle ear, for the assessment of the usefulness of this material in reconstructive middle-ear surgery. The exudate filling the pores during the eariy post-operative period was gradually replaced by equal amounts of fibrous tissue and bone. The percentage of the macropore area occupied by bone was directly correlated with the macropore size. Bone was deposited not only from the pore wall towards the pore centre, but also in the opposite direction. Bonding osteogenesis was demonstrated. At sites of mechanical irritation, the presence of multinucleated cells and proliferatively active mononuclear phagocytes persisted for as long as a year. Under appropriate conditions hydroxyapatite seems to be a promising material for bone substitution in reconstructive middle-ear surgery.