Nicotinic acetylcholine binding sites in Alzheimer's disease

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [ 3Hacetylcholine and [ 3Hnicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissue...

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Veröffentlicht in:	Brain research 1986-04, Vol.371 (1), p.146-151
Hauptverfasser:	Whitehouse, Peter J., Martino, Andrea M., Antuono, Piero G., Lowenstein, Pedro R., Coyle, Joseph T., Price, Donald L., Kellar, Kenneth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - metabolism Aged Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - metabolism Alzheimer's disease Biological and medical sciences Cerebral Cortex - analysis Cerebral Cortex - enzymology Cerebral Cortex - metabolism choline acetyltransferase Choline O-Acetyltransferase - metabolism cortex Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans man Medical sciences Neurology Nicotine - metabolism nicotinic cholinergic receptor Receptors, Nicotinic - analysis
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Zusammenfassung:	In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [ 3Hacetylcholine and [ 3Hnicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(86)90819-X