Influence of nitrous oxide upon regional brain levels of methionine-enkephalin-like immunoreactivity in rats

The influence of a 60-min exposure to 75% nitrous oxide/25% oxygen upon concentrations of methionine-enkephalin-like immunoreactivity (MELI) in discrete brain regions was investigated in conscious rats. Compared to room air-exposed control animals, nitrous oxide-exposed rats had 12–18% increases in...

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Veröffentlicht in:	Brain research bulletin 1986-03, Vol.16 (3), p.321-323
Hauptverfasser:	Quock, Raymond M., Kouchich, F.Jay, Liang-Fu, Tseng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics. Neuromuscular blocking agents Animals Applied sciences Biological and medical sciences Brain - metabolism Enkephalin, Methionine - metabolism Exact sciences and technology Male Medical sciences Methionine-enkephalin Neuropharmacology Nitrous oxide Nitrous Oxide - pharmacology Other techniques and industries Pharmacology. Drug treatments Radioimmunoassay Rats Rats, Inbred Strains Tissue Distribution
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Beschreibung
Zusammenfassung:	The influence of a 60-min exposure to 75% nitrous oxide/25% oxygen upon concentrations of methionine-enkephalin-like immunoreactivity (MELI) in discrete brain regions was investigated in conscious rats. Compared to room air-exposed control animals, nitrous oxide-exposed rats had 12–18% increases in MELI in the brainstem, spinal cord, hypothalamus and corpus striatum. There were no significant differences between control and nitrous oxide-exposed rats in levels of MELI in the cerebral cortex or diencephalon.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/0361-9230(86)90052-3