Pharmacokinetics of Atracurium and its Metabolites

Pharmacokinetics of Atracurium and its Metabolites

The pharmacokinetic profile of atracurium was studied in normal patients and in patients with renal failure, renal-hepatic failure, or hepatic disease. Its short elimination half-life was not significantly altered by renal failure, but in patients with severe liver disease elimination of its metabol...

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Veröffentlicht in:British journal of anaesthesia : BJA 1986-01, Vol.58 (suppl-1), p.6S-10S
Hauptverfasser: Ward, S., Weatherley, B.C.
Format: Artikel
Sprache:eng
Schlagworte:
Atracurium
Chronic Disease
Half-Life
Humans
Isoquinolines - metabolism
Kidney Failure, Chronic - metabolism
Kinetics
Liver Diseases - metabolism
Metabolic Clearance Rate
Neuromuscular Blocking Agents - metabolism
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Zusammenfassung:The pharmacokinetic profile of atracurium was studied in normal patients and in patients with renal failure, renal-hepatic failure, or hepatic disease. Its short elimination half-life was not significantly altered by renal failure, but in patients with severe liver disease elimination of its metabolites was prolonged, necessitating care during long-term i.v. infusions in patients with hepatic dysfunction.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.suppl_1.6S