Novel Bioactive Diterpenoids from Aframomum aulacocarpos

Three new labdane diterpenes, 12 alpha,17-epoxy-3 beta-hydroxy-8(9),13- labdadien-16,15-olide (aulacocarpinolide) [1], methyl 8 beta,17:14 zeta,15-diepoxy-3 beta-hydroxy- 12E-labden-16-oate (aulacocarpin A) [2], and methyl 8 beta,17:14 zeta,15-diepoxy-3 beta,6 beta- dihydroxy-12E-labden-16-oate (aul...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1994-07, Vol.57 (7), p.917-923
Hauptverfasser:	Ayafor, J. Foyere, Tchuendem, Marguerite H. K, Nyasse, Barthelemy, Tillequin, François, Anke, Heidrun
Format:	Artikel
Sprache:	eng
Schlagworte:	AFRAMOMUM Africa Animals ANTIMICROBIAL PROPERTIES Bacillus subtilis - drug effects CAMEROON CAMEROUN CAMERUN CHEMICAL COMPOSITION COMPOSICION QUIMICA COMPOSITION CHIMIQUE CYTOTOXIC COMPOUNDS DITERPENES Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology DITERPENOIDE DITERPENOIDS DITERPENOS Drug Screening Assays, Antitumor ESPECTROMETRIA FRUITS FRUTAS Humans labdane diterpenes Leukemia L1210 - drug therapy Magnetic Resonance Spectroscopy Microbial Sensitivity Tests MOLECULAR CONFORMATION Molecular Structure Mucor - drug effects Plants - chemistry PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE Seeds - chemistry SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY SUBSTANCE TOXIQUE SUSTANCIAS TOXICAS TOXIC SUBSTANCES
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Zusammenfassung:	Three new labdane diterpenes, 12 alpha,17-epoxy-3 beta-hydroxy-8(9),13- labdadien-16,15-olide (aulacocarpinolide) [1], methyl 8 beta,17:14 zeta,15-diepoxy-3 beta-hydroxy- 12E-labden-16-oate (aulacocarpin A) [2], and methyl 8 beta,17:14 zeta,15-diepoxy-3 beta,6 beta- dihydroxy-12E-labden-16-oate (aulacocarpin B) [3] have been isolated from the Cameroonian spice, Aframomum aulacocarpos, and their structures elucidated using spectroscopic techniques. The known bioactive diterpene dialdehyde, 8 beta,17-epoxy-12E-labdene-15,16-dial (aframodial) [4] was also isolated. Compounds 1-3 showed weak antimicrobial and cytotoxic activities.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50109a007