Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin: Preliminary evaluation of its biological activities
Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and ident...
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| Veröffentlicht in: | FEBS letters 1986-05, Vol.200 (1), p.181-185 |
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| creator | Audousset-Puech, M.P. Dufour, M. Kervran, A. Jarrousse, C. Castro, B. Bataille, D. Martinez, J. |
| description | Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone. |
| doi_str_mv | 10.1016/0014-5793(86)80535-X |
| format | Article |
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The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(86)80535-X</identifier><identifier>PMID: 3009226</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Cell Membrane - metabolism ; Chromatography, High Pressure Liquid ; Fundamental and applied biological sciences. 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The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.</description><subject>Amino Acid Sequence</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric acid secretionOxyntomodulinSolid-phase peptide synthesis</subject><subject>Gastrointestinal Hormones</subject><subject>Glucagon-Like Peptides - analogs & derivatives</subject><subject>Glucagon-Like Peptides - chemical synthesis</subject><subject>Glucagon-Like Peptides - pharmacology</subject><subject>Humans</subject><subject>Indicators and Reagents</subject><subject>Kinetics</subject><subject>Liver - metabolism</subject><subject>Oxyntomodulin</subject><subject>Proteins</subject><subject>Rats</subject><subject>Receptors, Cell Surface - drug effects</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Glucagon</subject><subject>Swine</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1DAUhoMo67j6DxR6IbJ7UU2aJk33QpDFL1hUUGHvQpqcOkfSppukg_vvzTjDXHp1CO_zHk4eQp4z-ppRJt9QytpadD2_UPJSUcFFffuAbJjqeM1bqR6SzQl5TJ6k9JuWt2L9GTnjlPZNIzfk7nvw6OplaxJUCywZHVTpfs5bSJiqMFbbdTLzxRcPddNd1uFPycIU3Opxvqq-RfA44WzifQU741eTMcz7GuZUDRh8-IXW-MrYjDvMCOkpeTQan-DZcZ6Tnx_e_7j-VN98_fj5-t1NbRtBc-2s6xxYNrRdyylIBdS6njLWC9O4kbXKsUFxMY7SDYMSwA11TI7DILu2AcnPyavD3iWGuxVS1hMmC96bGcKadCcVpVywArYH0MaQUoRRLxGn8iPNqN6b1nuNeq9RK6n_mda3pfbiuH8dJnCn0lFtyV8ec5OKgTGa2WI6YYo2jepFwd4eMCgudghRJ4swW3AYwWbtAv7_jr9NY5xe</recordid><startdate>19860505</startdate><enddate>19860505</enddate><creator>Audousset-Puech, M.P.</creator><creator>Dufour, M.</creator><creator>Kervran, A.</creator><creator>Jarrousse, C.</creator><creator>Castro, B.</creator><creator>Bataille, D.</creator><creator>Martinez, J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860505</creationdate><title>Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin: Preliminary evaluation of its biological activities</title><author>Audousset-Puech, M.P. ; Dufour, M. ; Kervran, A. ; Jarrousse, C. ; Castro, B. ; Bataille, D. ; Martinez, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-dcd7dec1b47430e68e0cd901195a2df148d1b835ff6dbb85e3a0d16fbb6742e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amino Acid Sequence</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric acid secretionOxyntomodulinSolid-phase peptide synthesis</topic><topic>Gastrointestinal Hormones</topic><topic>Glucagon-Like Peptides - analogs & derivatives</topic><topic>Glucagon-Like Peptides - chemical synthesis</topic><topic>Glucagon-Like Peptides - pharmacology</topic><topic>Humans</topic><topic>Indicators and Reagents</topic><topic>Kinetics</topic><topic>Liver - metabolism</topic><topic>Oxyntomodulin</topic><topic>Proteins</topic><topic>Rats</topic><topic>Receptors, Cell Surface - drug effects</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Glucagon</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Audousset-Puech, M.P.</creatorcontrib><creatorcontrib>Dufour, M.</creatorcontrib><creatorcontrib>Kervran, A.</creatorcontrib><creatorcontrib>Jarrousse, C.</creatorcontrib><creatorcontrib>Castro, B.</creatorcontrib><creatorcontrib>Bataille, D.</creatorcontrib><creatorcontrib>Martinez, J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Audousset-Puech, M.P.</au><au>Dufour, M.</au><au>Kervran, A.</au><au>Jarrousse, C.</au><au>Castro, B.</au><au>Bataille, D.</au><au>Martinez, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin: Preliminary evaluation of its biological activities</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1986-05-05</date><risdate>1986</risdate><volume>200</volume><issue>1</issue><spage>181</spage><epage>185</epage><pages>181-185</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. 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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1986-05, Vol.200 (1), p.181-185 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76800351 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Membrane - metabolism Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Gastric acid secretionOxyntomodulinSolid-phase peptide synthesis Gastrointestinal Hormones Glucagon-Like Peptides - analogs & derivatives Glucagon-Like Peptides - chemical synthesis Glucagon-Like Peptides - pharmacology Humans Indicators and Reagents Kinetics Liver - metabolism Oxyntomodulin Proteins Rats Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Glucagon Swine |
| title | Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin: Preliminary evaluation of its biological activities |
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