Solid-phase peptide synthesis of human(Nle-27)-oxyntomodulin: Preliminary evaluation of its biological activities

Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and ident...

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Veröffentlicht in:	FEBS letters 1986-05, Vol.200 (1), p.181-185
Hauptverfasser:	Audousset-Puech, M.P., Dufour, M., Kervran, A., Jarrousse, C., Castro, B., Bataille, D., Martinez, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Membrane - metabolism Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Gastric acid secretionOxyntomodulinSolid-phase peptide synthesis Gastrointestinal Hormones Glucagon-Like Peptides - analogs & derivatives Glucagon-Like Peptides - chemical synthesis Glucagon-Like Peptides - pharmacology Humans Indicators and Reagents Kinetics Liver - metabolism Oxyntomodulin Proteins Rats Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Glucagon Swine
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Beschreibung
Zusammenfassung:	Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by a basic octapeptide. The analogue (Nle-27)-oxyntomodulin of the human sequence has been synthesized by solid-phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(86)80535-X