Elevated serum concentrations of CA-125 in patients with advanced endometriosis
CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and35U/ml. Immunocytochemical...
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| Veröffentlicht in: | Fertility and sterility 1986-05, Vol.45 (5), p.630-634 |
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| container_title | Fertility and sterility |
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| creator | Barbieri, Robert L. Niloff, Jonathan M. Bast, Robert C. Schaetzl, Elena Kistner, Robert W. Knapp, Robert C. |
| description | CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and35U/ml. Immunocytochemical techniques demonstrated the presence of CA-125 on the cell surface of endometriotic lesions. |
| doi_str_mv | 10.1016/S0015-0282(16)49333-7 |
| format | Article |
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Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and<1% of apparently healthy controls have elevated peripheral blood levels of CA-125. Because endometriotic lesions are likely to be derivatives of embryonic coelomic epithelium, the authors investigated serum CA-125 levels in patients with endometriosis. Preoperative serum CA-125 concentrations were measured in 147 patients undergoing diagnostic laparoscopy or laparotomy. Serum CA-125 concentrations were elevated in patients with stage III or IV endometriosis, compared with controls with negative diagnostic laparoscopies (66.5±14.5 verses 8.20±0.59 U/ml, mean±standard error of the mean; P<0.001). Fifty-four percent of patients with stage III or IV endometriosis and 0% of the controls had CA-125 levels>35 U/ml. Occasional patients with stage II endometriosis (13%), leiomyomata uteri (14%), and chornic pelvic inflammatory disease (5%) also had serum CA-125 concentrations>35U/ml. Immunocytochemical techniques demonstrated the presence of CA-125 on the cell surface of endometriotic lesions.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)49333-7</identifier><identifier>PMID: 3457709</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Antigens, Neoplasm - analysis ; Antigens, Tumor-Associated, Carbohydrate ; Applied sciences ; Biological and medical sciences ; Chronic Disease ; Endometriosis - immunology ; Endometriosis - pathology ; Exact sciences and technology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Histocytochemistry ; Humans ; Immunoassay - methods ; Leiomyoma - immunology ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Non tumoral diseases ; Other techniques and industries ; Pelvic Inflammatory Disease - immunology ; Uterine Neoplasms - immunology ; Uterine Neoplasms - pathology</subject><ispartof>Fertility and sterility, 1986-05, Vol.45 (5), p.630-634</ispartof><rights>1986 American Society for Reproductive Medicine</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-24f4578d57896df216aba8a2be0d18d5e407f99160ef1d3922eb3017cdd853583</citedby><cites>FETCH-LOGICAL-c470t-24f4578d57896df216aba8a2be0d18d5e407f99160ef1d3922eb3017cdd853583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)49333-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8108947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8113634$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3457709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbieri, Robert L.</creatorcontrib><creatorcontrib>Niloff, Jonathan M.</creatorcontrib><creatorcontrib>Bast, Robert C.</creatorcontrib><creatorcontrib>Schaetzl, Elena</creatorcontrib><creatorcontrib>Kistner, Robert W.</creatorcontrib><creatorcontrib>Knapp, Robert C.</creatorcontrib><title>Elevated serum concentrations of CA-125 in patients with advanced endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and<1% of apparently healthy controls have elevated peripheral blood levels of CA-125. Because endometriotic lesions are likely to be derivatives of embryonic coelomic epithelium, the authors investigated serum CA-125 levels in patients with endometriosis. Preoperative serum CA-125 concentrations were measured in 147 patients undergoing diagnostic laparoscopy or laparotomy. Serum CA-125 concentrations were elevated in patients with stage III or IV endometriosis, compared with controls with negative diagnostic laparoscopies (66.5±14.5 verses 8.20±0.59 U/ml, mean±standard error of the mean; P<0.001). Fifty-four percent of patients with stage III or IV endometriosis and 0% of the controls had CA-125 levels>35 U/ml. Occasional patients with stage II endometriosis (13%), leiomyomata uteri (14%), and chornic pelvic inflammatory disease (5%) also had serum CA-125 concentrations>35U/ml. Immunocytochemical techniques demonstrated the presence of CA-125 on the cell surface of endometriotic lesions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Antigens, Tumor-Associated, Carbohydrate</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Endometriosis - immunology</subject><subject>Endometriosis - pathology</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Immunoassay - methods</subject><subject>Leiomyoma - immunology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Non tumoral diseases</subject><subject>Other techniques and industries</subject><subject>Pelvic Inflammatory Disease - immunology</subject><subject>Uterine Neoplasms - immunology</subject><subject>Uterine Neoplasms - pathology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_QchBRA-r-dgkuycppX6A4EE9hzSZxcjupibbiv_e1JZeewghM89kXh6ELii5pYTKuzdCqCgIq9g1lTdlzTkv1AEaUSFkIaTgh2i0Q07QaUpfhBBJFTtGx7wUSpF6hF5nLazMAA4niMsO29Bb6IdoBh_6hEODp5OCMoF9jxe5mHsJ__jhExu3Mpl1GHoXOhiiD8mnM3TUmDbB-fYeo4-H2fv0qXh5fXyeTl4KWyoyFKxscoLK5VNL1zAqzdxUhs2BOJrLUBLV1DWVBBrqeM0YzDmhyjpXCS4qPkZXm38XMXwvIQ2688lC25oewjJpJVVd1SXLoNiANoaUIjR6EX1n4q-mRK9F6n-Rem1J59e_SK3y3MV2wXLegdtNbc3l_uW2b5I1bROzDJ92WEUpl7zcj5Gccr3tfoNBdrbyEHWy2XXW6yPYQbvg9-T9A_Icmuk</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Barbieri, Robert L.</creator><creator>Niloff, Jonathan M.</creator><creator>Bast, Robert C.</creator><creator>Schaetzl, Elena</creator><creator>Kistner, Robert W.</creator><creator>Knapp, Robert C.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Elevated serum concentrations of CA-125 in patients with advanced endometriosis</title><author>Barbieri, Robert L. ; Niloff, Jonathan M. ; Bast, Robert C. ; Schaetzl, Elena ; Kistner, Robert W. ; Knapp, Robert C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-24f4578d57896df216aba8a2be0d18d5e407f99160ef1d3922eb3017cdd853583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Antigens, Tumor-Associated, Carbohydrate</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Endometriosis - immunology</topic><topic>Endometriosis - pathology</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Immunoassay - methods</topic><topic>Leiomyoma - immunology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Non tumoral diseases</topic><topic>Other techniques and industries</topic><topic>Pelvic Inflammatory Disease - immunology</topic><topic>Uterine Neoplasms - immunology</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbieri, Robert L.</creatorcontrib><creatorcontrib>Niloff, Jonathan M.</creatorcontrib><creatorcontrib>Bast, Robert C.</creatorcontrib><creatorcontrib>Schaetzl, Elena</creatorcontrib><creatorcontrib>Kistner, Robert W.</creatorcontrib><creatorcontrib>Knapp, Robert C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbieri, Robert L.</au><au>Niloff, Jonathan M.</au><au>Bast, Robert C.</au><au>Schaetzl, Elena</au><au>Kistner, Robert W.</au><au>Knapp, Robert C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated serum concentrations of CA-125 in patients with advanced endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>45</volume><issue>5</issue><spage>630</spage><epage>634</epage><pages>630-634</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and<1% of apparently healthy controls have elevated peripheral blood levels of CA-125. Because endometriotic lesions are likely to be derivatives of embryonic coelomic epithelium, the authors investigated serum CA-125 levels in patients with endometriosis. Preoperative serum CA-125 concentrations were measured in 147 patients undergoing diagnostic laparoscopy or laparotomy. Serum CA-125 concentrations were elevated in patients with stage III or IV endometriosis, compared with controls with negative diagnostic laparoscopies (66.5±14.5 verses 8.20±0.59 U/ml, mean±standard error of the mean; P<0.001). Fifty-four percent of patients with stage III or IV endometriosis and 0% of the controls had CA-125 levels>35 U/ml. Occasional patients with stage II endometriosis (13%), leiomyomata uteri (14%), and chornic pelvic inflammatory disease (5%) also had serum CA-125 concentrations>35U/ml. Immunocytochemical techniques demonstrated the presence of CA-125 on the cell surface of endometriotic lesions.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3457709</pmid><doi>10.1016/S0015-0282(16)49333-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1986-05, Vol.45 (5), p.630-634 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antigens, Neoplasm - analysis Antigens, Tumor-Associated, Carbohydrate Applied sciences Biological and medical sciences Chronic Disease Endometriosis - immunology Endometriosis - pathology Exact sciences and technology Female Female genital diseases Gynecology. Andrology. Obstetrics Histocytochemistry Humans Immunoassay - methods Leiomyoma - immunology Medical sciences Middle Aged Neoplasm Staging Non tumoral diseases Other techniques and industries Pelvic Inflammatory Disease - immunology Uterine Neoplasms - immunology Uterine Neoplasms - pathology |
| title | Elevated serum concentrations of CA-125 in patients with advanced endometriosis |
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