Striatal dopamine does not appear involved in the voluntary intake of ethanol by rats

Striatal dopamine does not appear involved in the voluntary intake of ethanol by rats

Ethanol preferring and non preferring rats were selected. Ethanol preferring rats showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily) while the non preferring rats drank less than 1 g/kg body weight daily. Preferring rats were daily IP injecte...

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Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 1986, Vol.3 (1), p.15-17
Hauptverfasser: Daoust, M., Moore, N., Saligaut, C., Lhuintre, J.P., Chretien, P., Boismare, F.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol Drinking
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Conditioning, Operant - drug effects
Corpus Striatum - physiology
Dopamine - physiology
Drinking
Ethanol
Male
Medical sciences
Nomifensine
Nomifensine - pharmacology
Rats
Striatal dopamine
Synaptosomes - metabolism
Taste - drug effects
Time Factors
Toxicology
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Zusammenfassung:Ethanol preferring and non preferring rats were selected. Ethanol preferring rats showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily) while the non preferring rats drank less than 1 g/kg body weight daily. Preferring rats were daily IP injected with 5 or 10 mg/kg of nomifensine, an inhibitor of dopamine uptake. Their intake of ethanol solution remained constant during the 14 days of treatment. Dopamine uptake into striatal synaptosomes was identical in ethanol preferring and non preferring rats. These data, as others, led us to suppose that striatal dopamine is not involved in the voluntary intake of ethanol by rats.
ISSN:0741-8329
1873-6823
DOI:10.1016/0741-8329(86)90065-0