Properties of rabbit erythrocytes treated with phospholipase A2 from bee venom

1. 1. In isotonic saline-buffered conditions, phospholipase A2 from bee venom cleaves up to 65% of the phosphatidylcholine of the rabbit RBC membrane without causing significant hemolysis; however, the volume and the osmotic fragility of the treated RBC is modified. 2. 2. The osmotic behaviour of PL...

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Veröffentlicht in:	Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1986, Vol.83 (4), p.715-719
Hauptverfasser:	Vaysse, J, Pilardeau, P, Garnier, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apis Apis mellifera Applied sciences Bee Venoms Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions enzyme activity Erythrocyte Membrane - analysis erythrocytes Erythrocytes - drug effects Exact sciences and technology Fundamental and applied biological sciences. Psychology Kinetics Membrane Lipids - blood Molecular and cellular biology osmosis Osmotic Fragility - drug effects Other techniques and industries phospholipase A2 Phospholipases - pharmacology Phospholipases A - metabolism Phospholipases A - pharmacology Phospholipases A2 phospholipids Phospholipids - blood Rabbits venom venoms
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Zusammenfassung:	1. 1. In isotonic saline-buffered conditions, phospholipase A2 from bee venom cleaves up to 65% of the phosphatidylcholine of the rabbit RBC membrane without causing significant hemolysis; however, the volume and the osmotic fragility of the treated RBC is modified. 2. 2. The osmotic behaviour of PLA-treated RBC after reincubation in autologous plasma suggests an heterogeneity in the enzymatic attack among the RBC population. 3. 3. In vivo RBC survival is strongly impaired by PLA treatment.
ISSN:	0300-9629
DOI:	10.1016/0300-9629(86)90715-2