Kinetics and substrate specificity of human and canine cytidine deaminase

Because of the importance of Cyd deaminase in the pharmacologic activity and toxicology of 1-(2'-deoxy-2'-fluoro- beta -D-arabinofuranosyl)-5-iodouracil FIAC and other newly synthesized 5-substituted arabinofuranosyl cytosine analogs, the authors examined how these compounds served as subs...

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Veröffentlicht in:	Biochemical pharmacology 1986-04, Vol.35 (7), p.1199-1201
Hauptverfasser:	Fanucchi, Michael P., Watanabe, Kyoichi A., Fox, Jack J., Ting-Chao, Chou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabinofuranosyluracil - analogs & derivatives Arabinofuranosyluracil - metabolism Biological and medical sciences Cytarabine - analogs & derivatives Cytarabine - metabolism Cytidine - metabolism cytidine deaminase Cytidine Deaminase - metabolism Deoxycytidine - metabolism Dogs Enzymes. Coenzymes. Vitamins. Pigments Fundamental and applied biological sciences. Psychology Humans Kinetics liver Liver - enzymology man Metabolisms and neurohumoral controls Nucleoside Deaminases - metabolism Substrate Specificity Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	Because of the importance of Cyd deaminase in the pharmacologic activity and toxicology of 1-(2'-deoxy-2'-fluoro- beta -D-arabinofuranosyl)-5-iodouracil FIAC and other newly synthesized 5-substituted arabinofuranosyl cytosine analogs, the authors examined how these compounds served as substrates for human and canine hepatic Cyd deaminase.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(86)90160-7