Homologous cholinergic efferents spared by partial fimbrial lesions contribute to the recovery of hippocampal cholinergic enzymes in adult rats

Cholinergic fibers spared by partial lesions of the fimbrial bundle contribute to the recovery of enzyme markers for hippocampal cholinergic terminals. This recovery, most likely representing structural restoration of cholinergic terminals lost to lesion-induced degeneration, is amplified by a ‘cond...

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Veröffentlicht in:	Brain research 1986-03, Vol.367 (1), p.368-373
Hauptverfasser:	Gasser, U.E., Van Deusen, E.B., Dravid, A.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism adult rat Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Choline O-Acetyltransferase - metabolism Cholinergic Fibers - physiology cholinergic neuron compensatory collateral sprouting Female fimbria Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - enzymology Hippocampus - physiology homotypic reinnervation Neural Pathways - physiology Neuronal Plasticity partial fimbrial lesion Rats recovery of cholinergic enzyme septohippocampal pathway Vertebrates: nervous system and sense organs Wound Healing
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Zusammenfassung:	Cholinergic fibers spared by partial lesions of the fimbrial bundle contribute to the recovery of enzyme markers for hippocampal cholinergic terminals. This recovery, most likely representing structural restoration of cholinergic terminals lost to lesion-induced degeneration, is amplified by a ‘conditioning’ lesion. This model of functionally relevant postlesion reconstruction, by and of structures within the CNS, is suitable to search for means to enhance homotypic collateral sprouting.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(86)91621-5