The B-cell antigen receptor complex: structure and signal transduction

The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex...

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Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1994-09, Vol.15 (9), p.393-399
Hauptverfasser:	Pleiman, Christopher M., D'Ambrosio, Daniele, Cambier, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Enzyme Precursors - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Intracellular Signaling Peptides and Proteins Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Molecular Sequence Data Protein-Tyrosine Kinases - immunology Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - immunology Signal Transduction - immunology Syk Kinase
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Beschreibung
Zusammenfassung:	The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.
ISSN:	0167-5699
DOI:	10.1016/0167-5699(94)90267-4