Effect of profound hypothermia on leukocytes and platelets

Seventeen patients who underwent aortic arch replacement were subjected to profound hypothermia and circulatory arrest. At maximum cooling, platelet count dropped from 184 +/- 122 to 37 +/- 30 thousand per microliter, and the total leukocytic count fell from 6.27 +/- 4.0 to 1.47 +/- 0.6 thousand per...

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Veröffentlicht in:	Annals of clinical and laboratory science 1986-03, Vol.16 (2), p.130-133
Hauptverfasser:	SHENAQ, S. A, YAWN, D. H, SALEEM, A, JOSWIAK, R, CRAWFORD, E. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aorta, Thoracic - surgery Aortic Aneurysm - surgery Biological and medical sciences Blood Platelets - cytology Hot Temperature Humans Hypothermia - blood Leukocyte Count Leukocytes - cytology Medical sciences Platelet Count Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Zusammenfassung:	Seventeen patients who underwent aortic arch replacement were subjected to profound hypothermia and circulatory arrest. At maximum cooling, platelet count dropped from 184 +/- 122 to 37 +/- 30 thousand per microliter, and the total leukocytic count fell from 6.27 +/- 4.0 to 1.47 +/- 0.6 thousand per microliter. The thrombocytopenia was partially reversed with rewarming. The total white cell count consistently returned to precooling values or higher (10.5 +/- 4.0). The mechanism for this cold induced phenomenon is not well understood.
ISSN:	0091-7370 1550-8080