Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro

Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar t...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1994-09, Vol.73 (3), p.315-317
Hauptverfasser:	DEVLIN, E.G., CLARKE, R.S.J., MIRAKHUR, R.K., MCNEILL, T.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaesthetic techniques Anaesthetic techniques, i.v. bolus Anesthetics, Intravenous - pharmacology Anesthetics. Neuromuscular blocking agents Biological and medical sciences Blood Blood, lymphocytes Cell Division - drug effects Cells, Cultured Depression, Chemical Dose-Response Relationship, Drug Etomidate - pharmacology Female Humans i.v. bolus Immune Tolerance - drug effects lymphocytes Male Medical sciences Methohexital - pharmacology Neuropharmacology Pharmacology. Drug treatments Phytohemagglutinins - immunology Propofol - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology Thiopental - pharmacology
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Zusammenfassung:	Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/73.3.315